Purpose: To examine the association of Insulin-like growth factor-1 (IGF-1) and binding protein-3 (IGFBP-3) with metabolic parameters of childhood obesity and assess its relationship with the presence of metabolic syndrome (MetS)
Methods: A cross-sectional study of total 307 children and adolescents referred for growth assessment was performed. Subjects were divided into three groups based on body mass index (BMI) percentile for age and gender. Anthropometric profiles and biochemical data were collected examining their association with IGF-1 and IGFBP-3.
Results: BMI was not significantly different in children with different quartile levels of IGF-1, IGFBP-3 and IGF-1/IGFBP-3 ratio. Alanine aminotransferase (β=-0.01, p<0.01), uric acid (β=-0.13, p<0.01) and total cholesterol (β=-0.01, p=0.01) were inversely associated with IGF-1 while not related to IGFBP-3 or IGF-1 to IGFBP-3 ratio. The prevalence of metabolic syndrome (MetS) was 11.2 % (63.64 % in males, 36.36 % in females) among children who were older than 10 years. IGF-1 was lower in children with MetS compared to ones without MetS (-1.51±0.93 vs. -0.32±1.10, p<0.01) whereas showed no difference among groups subdivided by BMI. Low IGF-1 (OR: 0.24, 95 % CI: 0.09-0.63, p<0.01) and high IGFBP-3 (OR: 5.28, 95 % CI: 1.96-14.21, p<0.01) were found to be risk factors for MetS. In children with MetS, IGF-1, IGFBP-3, or IGF-1 to IGFBP-3 ratio had no significant association with individual components of MetS.
Conclusion: IGF-1 and IGFBP-3 may be another key factor related to metabolic parameter of obesity and the presence of MetS of youth. Elucidating the role of IGFs might help to understand its metabolic action in obesity related condition.
19 - 21 Sep 2019
European Society for Paediatric Endocrinology