Introduction: Oral/enteral caloric intake (KOE) insufficiency may accompany human newborn (NWB) respiratory derangements. We detected axillary temperature(TEMP) relations to NWB blood serum Insulin-like Growth Factor-II(IG2)-blood serum Insulin-like Growth Factor-Binding Protein-3(IB3) ratios(IG2/IB3R). Here we evaluate the TEMP-independent relevance of birth gestational age(GA) and KOE to relationships of O2 supplementation in respiratory gases(O2S) with IG2/IB3R in not-life-threatened NWBs.
Methods: NWBs with any among total parenteral nutrition, parenteral nutrition other than dextrose, blood component transfusion, postnatal corticosteroid treatment, therapeutic hypothermia, life-threatening disease, diabetes mellitus(DM), endocrine diagnosis out of DM, malformation, and mother with DM were excluded. Each of 78 included NWBs had complete data availability for 1) same-day records at one of the first 5 postnatal days(x), 5 days after x(y) and 10 days after x(z) of postnatal age(PNA, unit:day), TEMP(unit:°C), total caloric intake(KT) and KOE (KT, KOE, unit: kcal/kg body weight/24hrs), pulse oximetry(SpO2, unit:%), O2S, IG2 and IB3 RIA measurements(unit:uM/dl), and for 2) gender(SEX), GA(unit:complete week; range=2842), GA<=36(preterm birth, n=46), BW(unit:g; range=12004150), BW<=10.th centile for GA(SGA). We calculated: 1) IG2/IB3R (IG2 through chronologically corresponding IB3), 2) averages over x-y-z times (i.e., (x+y+z)/3), for TEMP(TEMPM; range=36.1-37.0), K(KM), KOE(KOEM), SpO2(SpO2M; range=87.3-100.0) and IG2/IB3(IG2/IB3M), and 3) percents of KOEM over KM (i.e., (KOEM through KM)x100, KOEM%KM; range=24.5-100.0). IG2/IB3M normal score according to van der Waerden(IG2/IB3M-NS) resulted near-normally distributed. Multiple Linear Regression(MLR) was used for analyses(MLR computations; male SEX, SGA, O2S at x(O2Sx), condition absent=0, condition present=1)(n; male SEX, 43; SGA, 20; O2Sx, 22).
Results: Partial correlaton coefficient (pcc) for partial correlation between O2Sx and outcome IG2/IB3M-NS was significant in MLR models bearing, as predictors, 1) SEX, SGA, PNA, TEMPM, KM and O2Sx (pcc, r2:.423, P=.0002) or 2) SEX, SGA, PNA, TEMPM, KM, O2Sx and SpO2M (pcc, r2: .403, P=.0004) but not 3) GA and/or KOEM%KM in addition to SEX, SGA, PNA, TEMPM, KM and O2Sx or 4) GA and/or KOEM%KM in addition to SEX, SGA, PNA, TEMPM, KM, O2Sx and SpO2M (MLR R2:.337-.465, always significant).
Conclusions: GA and/or KOEM%KM may be involved in SO2x - IG2/IB3M-NS relations after control for TEMPM in addition to SEX, SGA, PNA, TEMPM, KM, and SpO2M.
19 - 21 Sep 2019
European Society for Paediatric Endocrinology