ESPE Abstracts (2019) 92 P2-150

Relations of O2 Supplementation to Blood Serum Insulin-like Growth Factor-II / Insulin-like Growth Factor-binding Protein-3 Ratios in the Not-life-threatened Human Newborn; Role of Oral-enteral Caloric Intake Beyond Axillary Temperature

Cesare Terzi1,2, Raffaele Virdis1,2, Cristiana Magnani3, Gabriele Tridenti3, Andrea Cerioli4, Marco Riani4, Elena Chesi3, Sergio Bernasconi1,2, Gian Luigi De Angelis1,2, Werner F. Blum5, Giacomo Banchini3


1Department of Medicine and Surgery, University of Parma, Parma, Italy. 2Department of Mother and Child, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy. 3Department of Obstetrics and Pediatrics, AUSL, Arcispedale S. Maria Nuova, IRCCS, Reggio Emilia, Reggio Emilia, Italy. 4Department of Economics, University of Parma, Parma, Italy. 5Children's Hospital, University of Giessen, Giessen, Germany


Introduction: Oral/enteral caloric intake (KOE) insufficiency may accompany human newborn (NWB) respiratory derangements. We detected axillary temperature(TEMP) relations to NWB blood serum Insulin-like Growth Factor-II(IG2)-blood serum Insulin-like Growth Factor-Binding Protein-3(IB3) ratios(IG2/IB3R). Here we evaluate the TEMP-independent relevance of birth gestational age(GA) and KOE to relationships of O2 supplementation in respiratory gases(O2S) with IG2/IB3R in not-life-threatened NWBs.

Methods: NWBs with any among total parenteral nutrition, parenteral nutrition other than dextrose, blood component transfusion, postnatal corticosteroid treatment, therapeutic hypothermia, life-threatening disease, diabetes mellitus(DM), endocrine diagnosis out of DM, malformation, and mother with DM were excluded. Each of 78 included NWBs had complete data availability for 1) same-day records at one of the first 5 postnatal days(x), 5 days after x(y) and 10 days after x(z) of postnatal age(PNA, unit:day), TEMP(unit:°C), total caloric intake(KT) and KOE (KT, KOE, unit: kcal/kg body weight/24hrs), pulse oximetry(SpO2, unit:%), O2S, IG2 and IB3 RIA measurements(unit:uM/dl), and for 2) gender(SEX), GA(unit:complete week; range=28–42), GA<=36(preterm birth, n=46), BW(unit:g; range=1200–4150), BW<=10.th centile for GA(SGA). We calculated: 1) IG2/IB3R (IG2 through chronologically corresponding IB3), 2) averages over x-y-z times (i.e., (x+y+z)/3), for TEMP(TEMPM; range=36.1-37.0), K(KM), KOE(KOEM), SpO2(SpO2M; range=87.3-100.0) and IG2/IB3(IG2/IB3M), and 3) percents of KOEM over KM (i.e., (KOEM through KM)x100, KOEM%KM; range=24.5-100.0). IG2/IB3M normal score according to van der Waerden(IG2/IB3M-NS) resulted near-normally distributed. Multiple Linear Regression(MLR) was used for analyses(MLR computations; male SEX, SGA, O2S at x(O2Sx), condition absent=0, condition present=1)(n; male SEX, 43; SGA, 20; O2Sx, 22).

Results: Partial correlaton coefficient (pcc) for partial correlation between O2Sx and outcome IG2/IB3M-NS was significant in MLR models bearing, as predictors, 1) SEX, SGA, PNA, TEMPM, KM and O2Sx (pcc, r2:.423, P=.0002) or 2) SEX, SGA, PNA, TEMPM, KM, O2Sx and SpO2M (pcc, r2: .403, P=.0004) but not 3) GA and/or KOEM%KM in addition to SEX, SGA, PNA, TEMPM, KM and O2Sx or 4) GA and/or KOEM%KM in addition to SEX, SGA, PNA, TEMPM, KM, O2Sx and SpO2M (MLR R2:.337-.465, always significant).

Conclusions: GA and/or KOEM%KM may be involved in SO2x - IG2/IB3M-NS relations after control for TEMPM in addition to SEX, SGA, PNA, TEMPM, KM, and SpO2M.