Aim: The aim of this study was to evaluate the effect of different doses of vitamin D supplementation on androgen levels in adolescent girls who were treated with metformin.
Method: 45 adolescent girls diagnosed with hyperandrogenism were divided into the 3 different groups according to the treatment scheme. Patients treated with metformin (850 mg / day oral)(n = 15), metformin and vitamin D drops (2,000 IU / day)(n=15), metformin and vitamin D ampoule (150,000 IU / month) (n=15) were examined as group 1, group 2 and group 3, respectively. Biochemical and hormonal parameters were compared statistically after 8 weeks.
Results: There was a significant positive correlation between total testosterone and ALT in group 1 and group 3 (P <0.05). There was a positive correlation between total testosterone and estradiol in group 1 and group3 (P = 0.00, P = 0.01, respectively). There was a positive correlation between SHBG and vitamin D and negative correlation between SHBG and androstenedione level in group 1. However, there were not any statistically significant difference between HOMA-IR (P = 0.46), total testosterone (P = 0.61), free testosterone (P = 0.69) and insulin (P = 0.61) over time.
Conclusion: Our study has shown that eight weeks' metformin and vitamin D supplementation did not have a positive effect on serum insulin levels, HOMA-IR, serum lipids, testosterone, androstenedione and DHEAS levels in adolescent girls with hyperandrogenism.
19 - 21 Sep 2019
European Society for Paediatric Endocrinology