ESPE Abstracts (2019) 92 P2-58

Skeleton Muscles and Tissues Metabolic Activity in Greek Adolescent PCOS

Styliani Geronikolou1,2,3, Dennis Cokkinos3, Flora Bacopoulou4


1First Dpt of Paediatrics, Athens University Med School,,Aghia Sophia Children's Hospital, Athens, Greece. 2University Research Institute of Maternal and Child health and Precision Medicine, Athens, Greece. 3Biomedical Research Foundation of the Academy of Athens, Athens, Greece. 4First Dpt of Paediatrics, Athens University,Aghia Sophia Children's Hospital, Athens, Greece


Background: The skeleton, which is strongly controlled by endocrine factors, has recently been shown to play an active endocrine role itself, specifically influencing energy metabolism. However, its role in polycystic ovary syndrome (PCOS) phenotype is underinvestigated.

Aim: Herein, we sought to identify novel factors involved in the regulation of both bone mass and whole-body homeostasis relevant to the disease.

Methods: In this pilot study, 10 PCOS (mean age 15.8 ± 3.2 years) vs 14 non-PCOS adolescents (mean age 15.1 ± 1.9 years), age and BMI matched underwent a body composition analysis by bioelectrical impedance, using a BIA phase-sensitive system (single-frequency 50 kHz). All participants did not have metallic implants of any kind in their body. The measurements took place in the Biomedical Research Foundation of the Academy of Athens( Stress and Metabolism Laboratory of the Clinical, Translational and Experimental Surgery Research Centre). The calculations were made non parametrically in SPSS 21.

Results: No differences in body cell mass (BCM) (P=0.716), extracellular mass (ECM) (P=0.128), skeletal muscle (P=1.00) were observed.

Conclusions: Metabolically active (BCM) and inactive (ECM) tissues of the body, as well as skeleton muscles show no differences in the two groups, perhaps due to the young of age. Future research should give a deeper insight to the subject investigating more markers by bioimpendance and/or biochemistry.

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