ESPE Abstracts (2019) 92 P2-64

Autoimmune Thyroid Diseases in Children and Adolescents with Maturity Onset Diabetes of the Young

Valeria Calcaterra, Corrado Regalbuto, Giulia Dobbiani, Federica Vinci, Chiara Montalbano, Daniela Larizza


University of Pavia and Fond. IRCCS Policlinico San Matteo, Pavia, Italy


Background and Aim: The relationship between T1DM and autoimmune thyreopathies is known and described, but the relationship between thyreopathies and other type of diabetes is not sufficiently clarified in pediatric age. The aim of our study was to assess the prevalence of autoimmune thyroid diseases (ATD) in children and adolescents with maturity onset diabetes of the young (MODY) in comparison with patients with T1DM and control group.

Patients and Methods: We examined 24 children and adolescent with MODY (11F/13M; 13.9±4.6 yr) and 166 patients with T1DM (80F/86M; 13.9±4.6 yr). The control group consisted of 62 age-matched healthy subjects (34F/28M). The diagnosis of ATD was based on autoantibodies examination (anti-TPO, anti-Tg, anti-TSHr), ultrasound picture and thyroid function test.

Results: ATD was diagnosed in 15 (10.5%; 9F/6M) patients with DMT1, in 5 (20.5%; 4F/1M) in MODY and finally in 1 control (1.6%). A significantly higher ATD prevalence was detected in T1DM and MODY compared to controls (P=0.02 and P=0.001, respectively), without difference between T1DM and in MODY (P=0.15). No difference was noted between genders in T1DM and MODY (P=0.8 and P=0.008, respectively).

Conclusion: Results show an increased prevalence of ATD in patients with MODY, as well as T1DM, resulting in recommendation of careful follow-up of all children and adolescents for presence of thyroid autoimmunity.

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