Objective: Ketosis-prone diabetes (KPD), characterized by presentation with diabetic ketoacidosis (DKA) in patients lacking the typical features of autoimmune type 1 diabetes, is a heterogeneous syndrome. The objective of this study is to ascertain the presence of A-β+ (autoantibody-negative, β-cell functional reserve) KPD in Korean children and adolescents and to study their characteristics in this group. Method: Diabetes patients (n = 9) with suspected KPD (A-β+) were studied over a period of 1 year with evaluation of clinical and biochemical characteristics. These were compared with a control group (n = 34) of KPD (A+β-). Preserved β-cell function after the index DKA was defined as fasting insulin serum C-peptide level > 1 ng/mL. Results: A-β+ KPD patients had a greater mean BMI and higher frequency of obesity, significantly older age than the A-β- KPD. On serial follow-up, the patients with A-β+ KPD achieved recovery of their beta-cell function. Conclusions: This is the first study to report of A-β+ KPD in Korean children and adolescents with evaluation of natural course of their diabetes. Our data showed that 9 out of the 49 patients who were admitted with DKA at diagnosis for diabetes characteristics of A-β+ KPD which suggested a prevalence rate of 18.4%.
19 - 21 Sep 2019
European Society for Paediatric Endocrinology