ESPE Abstracts (2019) 92 P2-85

Clinical Characteristics and Treatment Outcomes in Patients with Autoantibody-negative Ketosis-prone Diabetes

Shin-Hee Kim1, Moon-Bae Ahn2, Seulki Kim3, Yujung Choi4, Seonhwa Lee 4, Won Kyoung Cho5, Kyoung Soon Cho6, Min Ho Jung7, Byung Kyu Suh8


1Department of Pediatrics, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea, Seoul, Korea, Republic of. 2Department of Pediatrics, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea, Seoul, Korea, Republic of. 3 Department of Pediatrics, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea, Seoul, Korea, Republic of. 4Department of Pediatrics, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea, Seoul, Korea, Republic of. 5Department of Pediatrics, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea, Seoul, Korea, Republic of. 6Department of Pediatrics, Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea, Seoul, Korea, Republic of. 7Department of Pediatrics, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea, Seoul, Korea, Republic of. 8Department of Pediatrics, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea, Seoul, Korea, Republic of


Objective: Ketosis-prone diabetes (KPD), characterized by presentation with diabetic ketoacidosis (DKA) in patients lacking the typical features of autoimmune type 1 diabetes, is a heterogeneous syndrome. The objective of this study is to ascertain the presence of A-β+ (autoantibody-negative, β-cell functional reserve) KPD in Korean children and adolescents and to study their characteristics in this group. Method: Diabetes patients (n = 9) with suspected KPD (A-β+) were studied over a period of 1 year with evaluation of clinical and biochemical characteristics. These were compared with a control group (n = 34) of KPD (A+β-). Preserved β-cell function after the index DKA was defined as fasting insulin serum C-peptide level > 1 ng/mL. Results: A-β+ KPD patients had a greater mean BMI and higher frequency of obesity, significantly older age than the A-β- KPD. On serial follow-up, the patients with A-β+ KPD achieved recovery of their beta-cell function. Conclusions: This is the first study to report of A-β+ KPD in Korean children and adolescents with evaluation of natural course of their diabetes. Our data showed that 9 out of the 49 patients who were admitted with DKA at diagnosis for diabetes characteristics of A-β+ KPD which suggested a prevalence rate of 18.4%.

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