Chronic kidney disease (CKD) is one of the most significant medical and socio-economic problems of our time.
Purpose of the Research: To study the prevalence of chronic kidney disease in children and adolescents with type 1 diabetes in Uzbekistan.
Materials and Methods: For conducting epidemiological studies there were examined children and adolescents of type 1 diabetes. Epidemiological data were studied on the basis of the developed protocols, filled in with children and adolescents of type 1 diabetes consisting in the dispensary registration in the specified areas.
Results and Discussion: The study of gender differences in the group of children and adolescents in type 1 diabetes revealed the prevalence of females in both 41.5 / 58.5% (n = 139/196) and adolescents 49.4 / 50, 6% (n = 128/131) groups. The majority of children with type 1 diabetes 80.6% in the surveyed regions were without CKD, 7.5% were in stage I of CKD; 6.6% in stage II CKD; 4.2% for III and 1.2% for Stage IV CKD. Among children with CKD (n = 65), the majority were mainly in stages I and II of CKD. In the Republic of Karakalpakstan and Surkhandarya regions among the examined children of type 1 DM, there were no cases of III and IV stages of CKD. However, IV stage of CKD was detected in the 1st child in the Khorezm region and in 3 children in the city of Tashkent. Thus, the majority of children with type 1 diabetes in the surveyed regions were in stages I and II of CKD.The majority of adolescents with type 1 diabetes 64.5% in the surveyed regions were without CKD, 17.0% were in stage I of CKD; 8.1% in stage II CKD; 4.6% for III and 5.8% for Stage IV CKD. Among the examined adolescents with type 1 diabetes, CKD stage V was not detected. Thus, the majority of the examined adolescents with type 1 diabetes in the regions were at stage I and II of CKD.
Conclusion: It is established that the actual prevalence of CKD: in children, 19.4% and in adolescents, 35.5%. Among children and adolescents with type 1 diabetes with the presence of CKD, most were in stage I and II of CKD. However, predominance of females among both 41.5 / 58.5% of children and 49.4 / 50.6% among adolescents, which plays an important role in the formation of risk groups for further research.
19 - 21 Sep 2019
European Society for Paediatric Endocrinology