ESPE Abstracts (2019) 92 P2-98

Prevalence of Neonatal Macrosomia (NM) and Its Relation to Hypoglycaemia (NH) in Normoglycemic Versus Dysglycemic Pregnant Women.

ASHRAF SOLIMAN, Husam Salama, Hilal Al Rifai, Sawsan Al-Obaidly, Mai Al Qubasi, Tawa Olukade


Hamad Medical Centre, Doha, Qatar


Introduction: Several factors contribute to the risk of neonatal macrosomia (NM) and its associated hypoglycemia (NH) in pregnant women.

Objective: To determine the prevalence of NM and its association with NH in a large cohort of normoglycemic and dysglycemic women.

Methods: Out of 12255 pregnant women screened during 2016-2017, 3027 women were identified with gestational diabetes (GDM) (WHO criteria) and 233 were diabetic (DM) before pregnancy. All dysglycemic women were managed according to related guideline/protocol with 3 or more clinical visits during the pregnancy period. Neonatal macrosomia (NM) is defined as an infant's birth weight of more than 4000 g at term. Neonatal hypoglycaemia (NH) was defined as a plasma glucose < 30 mg/dL in the first day of life and < 45 mg/dL thereafter. Data on neonatal outcome was collected the hospital records as a part of a PEARL-Peristat Study, funded by QNRF- Doha-Qatar.

Results: GDM and DM women had a higher prevalence of NM. In addition, macrosomic newborns of dysglycemic mothers had a higher prevalence of NH compared to MN of normoglycemic mothers. the major risk factors for macrosomia which were compared with the normal weight infant groups (for all parameters). (table)

Table: Macrosomia and associated hypoglycemia in Normoglycemic and dysglycemic women
Mothers
BabiesNo DMGDMDM
Liveborn89263018233
NICU admissions107648358
Macrosomic babies44720515
Macrosomia + hypoglycemia requiring NICU admission out of liveborn0.078%0.26%*1.29%*
Macrosomia + hypoglycemia requiring NICU Admission out of all macrosomia babies7 (1.57%)8 (3.9%)*3 (20%) *
*P<0.05

Conclusion: Neonatal macrosomia is still more prevalent in treated women with DM and GDM. It appears that macrosomic infants of dysglycemic mothers are in greater risk of having severe hypoglycemia requiring NICU admission compared to MN of normoglycemic women.

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