Purpose: Vitamin D deficiency is thought to be influenced by cardiovascular function and glucose homeostasis, however the potential influence of vitamin D status on insulin resistance, is not well understood. The aim is investigate the correlations between 25-hydroxyvitamin D[25(OH)D] with adiposity assessed by body mass index(BMI), fasting glucose and lipid levels on schoolchildren.
Methods: From April 2015 to July 2018, 822 patients aged 6 to 18 years who visited the pediatrics outpatient clinics for adolescent developmental evaluation were included. Of the 822 patients, 255 male (31.0%) and 567 female (69.0%) were assessed. According to the vitamin D status, the patients were divided into three groups: under 10 ng/ml, 11 to 20 ng/ml, and over 20 ng/ml, which were classified as the deficiency, insufficiency, and normal group. Logistic regression was used to measure correlations in between 25(OH)D with BMI, serum glucose and lipids levels according to sex and puberty.
Results: Each BMI level according to vitamin D status were 18.1 ± 3.2 kg/m2, 17.6 ± 3.1 kg/m2, and 16.8 ± 2.9 kg/m2, respectively (P = 0.004). BMI showed a statistically significant negative linear correlation with 25(OH)D (rho = -0.143, P = 0.000). Sex difference of 25(OH)D was significant in girls (P = 0.04), but was no significant difference in boys. Difference were found between 25(OH)D and BMI groups in pubertal changes. Furthermore, In accordance with sex and puberty, no correlation were observed between 25(OH)D and blood sugar, or between 25(OH)D and cholesterol.
Conclusions: Higher 25(OH) D levels in children showed lower BMI with a weak negative linear correlation. However, the effect of vitamin D on blood glucose and cholesterol levels was not significant. It seems to be no effect on sex and pubertal changes. Longitudinal studies are to explore whether vitamin D deficiency affect hyperglycemia, hyperlipidemia, insulin resistance and diabetes.
19 - 21 Sep 2019
European Society for Paediatric Endocrinology