Objectives: Non-high-density lipoprotein (HDL) cholesterol is an alternative method to assess dyslipidemia and is not required fasting. We aimed to assess the validity of non-HDL cholesterol for detecting dyslipidemia among Korean adolescents.
Subjects and Methods: Data for 6,989 adolescents aged 10 to 19 years (3,684 boys and 3,305 girls), were obtained from the Korean National Health and Nutrition Examination Surveys during 2008-2016. Dyslipidemia was defined by having one of the followings; total cholesterol ≥200 mg/dL, triglyceride ≥130 mg/dL, low-density lipoprotein (LDL) cholesterol ≥130 mg/dL, or HDL cholesterol <40 mg/dL. Non-HDL cholesterol ≥145 mg/dL was used to detect dyslipidemia based on National Heart, Lung, and Blood Institute 2011.
Results: The overall prevalence of dyslipidemia were 27% and 37% among Korean adolescents based on calculated and measured LDL cholesterol level, respectively. The prevalence of non-HDL cholesterol level ≥145 mg/dL were 7.1% and 8.5% in teenage boys and girls, respectively. High non-HDL level were found in 97.1% and 97.7% of teenage boys and girls with dyslipidemia, respectively. The odds ratio for having dyslipidemia in adolescents with high non-HDL cholesterol level compared with normal level were 75 and 112 in teenage boys and girls, respectively. High non-HDL cholesterol level especially detected 96.3% and 95.2% of high measured LDL-cholesterol level in teenage boys and girls (P<0.001 and P<0.001, respectively). Prevalence of having parental history of dyslipidemia were similar whether adolescents had high non-HDL cholesterol level or not (P=0.640 and P=0.506, respectively).
Conclusions: Non-HDL cholesterol appeared to be a reliable dyslipidemia screening test also in adolescents and easily calculated from random sample not required fasting.
19 - 21 Sep 2019
European Society for Paediatric Endocrinology