ESPE Abstracts (2019) 92 P3-133

Relations of O2 Supplementation to Blood Serum Insulin-Like Growth Factor-I in the Not-Life-Threatened Human Newborn; Role of Oral-Enteral Caloric Intake Beyond Axillary Temperature

Cesare Terzi1,2, Werner F Blum3, Cristiana Magnani4, Gabriele Tridenti4, Andrea Cerioli5, Marco Riani4, Lidia Garavelli4, Sergio Bernasconi1,2, Gian Luigi De Angelis1,2, Raffaele Virdis1,2, Giacomo Banchini4


1Department of Medicine and Surgery, University of Parma, Parma, Italy. 2Department of Mother and Child, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy. 3Childre's Hospital University of Giessen, Giessen, Germany. 4Department of Obstetrics and Pediatrics, AUSL, Arcispedale S. Maria Nuova, IRCCS, Reggio Emilia, Reggio Emilia, Italy. 5Department of Economics, University of Parma, Parma, Italy


Introduction: Human newborn(NWB) respiratory derangements may be concomitant to oral/enteral caloric intake (KOE) insufficiency. We evidenced a possible involvement of axillary temperature(TEMP) in relationships between preterm birth (PTB) and blood serum Insulin-like Growth Factor-I(IG1) in NWBs. Here we evaluate the TEMP-independent role of birth gestational age(GA) and KOE in relations of O2 supplementation in respiratory gases(O2S) to IG1 in the not-life-threatened NWB.

Methods: NWBs with any among total parenteral nutrition, parenteral nutrition other than dextrose, blood component transfusion, postnatal corticosteroid treatment, therapeutic hypothermia, life-threatening disease, diabetes mellitus(DM), endocrine diagnosis out of DM, malformation, and mother with DM were excluded. Each of 78 included NWBs had complete data availability for 1) same-day records at one of the first 5 postnatal days(x), 5 days after x(y) and 10 days after x(z) of postnatal age(PNA, unit:day), TEMP(unit:°C), total caloric intake(K) and KOE(K, KOE, unit: kcal/kg body weight/24hrs), pulse oximetry(SpO2, unit: %), O2S, and IG1 RIA measurements(unit:uM/dl), and for 2) gender(SEX), GA(unit:complete week; range=28–42), GA<=36(preterm birth, n=46), BW(unit:g; range=1200–4150), BW<=10.th centile for GA(SGA). We calculated: 1) averages over x-y-z times (i.e., (x+y+z)/3) for TEMP(TEMPM; range=36.1-37.0), IG1(IG1M), K(KM), KOE(KOEM), and SpO2(SpO2M; range=87.3-100.0), and 2) percents of KOEM over KM (i.e., (KOEM through KM)x100), KOEM%KM; range=24.5-100.0). IG1M normal score according to van der Waerden(IG1M-NS) resulted near-normally distributed. Multiple Linear Regression(MLR) was used for analyses(MLR computations; male SEX, SGA, O2S at x(O2Sx), condition absent=0, condition present=1)(n; male SEX, 43; SGA, 20; O2Sx, 22).

Results: Partial correlaton coefficient (pcc) for partial correlation between O2Sx and outcome IG1M-NS was significant in MLR models bearing, as predictors, 1) SEX, SGA, PNA, TEMPM, KM and O2Sx (pcc, r2: -.391, P=.001) or 2) SEX, SGA, PNA, TEMPM, KM, O2Sx and SpO2M (pcc, r2: -.379, P=.001) but not 3) GA and/or KOEM%KM in addition to SEX, SGA, PNA, TEMPM, KM and O2Sx or 4) GA and/or KOEM%KM in addition to SEX, SGA, PNA, TEMPM, KM, O2Sx and SpO2M (MLR R2:.351-.550, always significant).

Conclusions: Factors related to GA and/or to KOEM%KM may be related to O2Sx - IG1M-NS relations after control for TEMPM in addition to SEX, SGA, PNA, TEMPM, KM, and SpO2M.