ESPE Abstracts (2019) 92 P3-199

Prolactinomas in a Pediatric Population

Liliana Mejia de Beldjenna 1,2,3, Sara Vanegas4, Matallana Audrey5,6, Mirey Siuffi7


1Foundation Clinic Club Noel, Cali, Colombia. 2Foundation Clinic Valle del Lili, Cali, Colombia. 3UNIVERSIDAD LIBRE, Cali, Colombia. 4Foundation Clinic Valle del Lili, Cali, Colombia. 5Universidad del Valle, Cali, Colombia. 6Hospital Universitario del Valle, Cali, Colombia. 7Clinic Farallones, Cali, Colombia


Introduction: Prolactinoma is the most frequent pituitary tumor (40 %) in children and adolescents is more common in females, sporadic and benign. It is classified into microprolactinoma (< 1.0 cm) and macroprolactinoma (>1.0 cm). In girls it presents clinically as amenorrhea and galactorrhea and occasionally as increased intracranial pressure. Management consist of medications and surgery.

Objectives: To characterize patients seen at Pediatric Endocrinology Clinics from three Institution between july 2000 and November 2018.

Materials and Methods: Review of charts from patients with prolactinoma.

Results are presented in table 1. micro: microadenoma, Macro: macroadenoma *F:female.M:male, n/a does not apply

PacientAge yearsSexGalactorrheaAmenorrheasizeProlactin. ng/mlsurgerydrugs
116FyesyesMacro470SiSi
27Fnonomicro500NoSi
313MNon/amicro651NoSi
413Fyesyesmicro67SiSi
515Fyesyesmacro542NoSi
614MNon/amicro81NoSi
715MNon/amacro400SiSi
88MNon/amacro1024SiSi
913MNon/amacro470NoSi
1010Myesn/amacro500nosi

Analysis: Ten patients, mean age 12.4±3.0 years, male 60%,40% female,60%debuted with galactorrhea,75% of women with amenorrhea,75% debuted with intracranial hypertension data 40% surgical management 60%had macroadenomas and 40% microadenomas, mean prolactin 470±271ng /ml.

Conclusions: We must suspect CNS tumors in patient with intracraneal hyppertension symtoms .Macroadenomas are more common in our pediatric population and as such surgery is the most common approach.

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