ESPE Abstracts (2019) 92 P3-205

Childhood Craniopharyngioma: A Single Centre Experience

Dario Gallo, Cristina Partenope, Roberta Pajno, Marco Pitea, Giovanna Weber, Graziano Barera, Gabriella Cinzia Pozzobon


San Raffaele Hospital, Milan, Italy


Backround: Craniopharingiomas are rare embryogenic malformations of the sellar and parasellar region with slow growth and high local recurrence rate. Due to their unfavorauble location, presurgical hypothalamic involvement and treatment-related hypothalamic damage is frequent and lead to hypothalamic syndrome.

Objective: we compare weigh gain and growth pattern regarding to hypothalamic involvement of pediatric patients affected by CF.

Materials and Method: we retrospectively review clinical data of 17 patients (8 female, 9 male) with childhood CF treated to our Centre. Median age of diagnosis was 8.1 ys with a median follow up time over 5 ys. Grading of hypothalamic involvement was based on neuradiological and surgical assessment. Growth hormone replacement was started to all patients after 6-12 months from tratment.

Results: BMI sds and Ht sds of 7/17 patients without hypothalamic involvement (41%):

DiagnosisSurgeryGH startPuberty ageLast FU visit
SDS BMI-0,49-0,30-0,110,390,60
SDS HT-1,55-1,96-2,25-1,55-0,38

10/17 patients had hypothalamic involvement (59%):

DiagnosisSurgeryGH startPuberty ageLast FU visit
SDS BMI0,591,441,951,762,53
SDS HT-0,84-1,35-1,49-0,87-0,02

Conclusions: Weight gain was significantly different between the two groups due to hypothalamic obesity. In the Hy group weight gain was moreover rapid and progressive. Growth hormone treatment improved growth in all patients with height sds within the normal limits at the last FU. Contrarily GH beneficial on weight appeared only temporarily.

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