ESPE Abstracts (2019) 92 P3-207

Precocious Puberty and Primary Hypothyroidism in a 6 Years and 10 Months Girl with Pituitary Macro Adenoma and Dextral Ovarian Cyst

Ratna Artati


Hasanuddin University/Dr Wahidin Sudirohusodo Hospital, Makassar, Indonesia


Background: Precocious puberty associated with profound hypothyroidism is a rare condition. It is usually characterized by breast development, vaginal bleeding, and lack of pubic hair. Multi cystic ovaries in profound hypothyroid patients with precocious puberty have been rarely described.

Case Presentation Summary: A 6 year and 10 month old girl was referred to Wahidin Hospital with precocious puberty. The girl was admitted with vaginal bleeding as the main complaint. Vaginal bleeding occurred since 6 months before with 3-4 days cycle. Breast enlargement and hairy axillary since a year before. Her mother had menarche at 14 years old. There was consanguinity of her both parents. On physical examination: pigmented hairy axillary, breast budding, no pubic hair. Body weight 20 kg, height 108 cm. Genetic height potential 142,5 cm - 159,5 cm (CDC NCHS 2000). Laboratory: hemoglobin 8,4 g/dl, perifer blood smear dismorphyc anemia from Fe deficiency with differential diagnosis chronic illness. Low LH but FSH and estradiol elevated. Low FT4, T3 (total) and T4 (total) with high TSHS and prolactin. Tumor marker: AFP, CEA and Beta HCG normal with light elevation in Ca-125. MSCT abdominal scan ovarial cystic. Bone age for left hand appropriate with 6 years and 10 months girl. Head CT scan suggestive pituitary macro adenoma, bilateral fronto temporal hypoplasia. This patient treated with levotiroxin 100 mcg/24 jam/oral.

Discussion: Precocious puberty associated with profound hypothyroidism is a rare condition and can be treated with levotiroxin which can give tumor reduction and stop bleeding.

Keywords: Precocious puberty, hypothyroidism, pituitary macro adenoma, levothyroxin

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