ESPE Abstracts (2019) 92 P3-222

Research on Detecting the Dose of Estrogen in the Hormone Replacement Treatment in Girls with TS – A Retrospective Study in Single Clinical Center

Song Guo, Qiuli Chen, Yanhong Li, Jun Zhang, Hongshan Chen, Huamei Ma, Minlian Du


The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China


Objective: The study was to detect the proper regimen of estrogen in HRT in girls with TS.

Method: We conducted a retrospective, longitudinal study with 76 girls with TS from The First Affiliated Hospital of Sun Yat-sen University over the past two decades.

Results: The investigation time was 3.00 (2.00, 4.66) yrs. The uterine volume grew significantly till B4 stage when compared with last stage (ZB2 vs. B1= -4.67, P< 0.001; ZB3 vs. B2= -2.137, P = 0.037; ZB4 vs. B3= -2.818, P = 0.005; ZB5 vs. B4= -0.868, P = 0.358). The uterine volume was positively relate to the estrogen dose in B3 and B4 stage (r = 0.447 and 0.586, P = 0.001 and <0.0001 respectively), and we found the value of 22ug/kg.d for B3 (value of dose: 17.5, 20, 22, and 23ug/kg.d, Z = -3.292, -3.207, -1.668, and -1.286, P = 0.001, 0.002, 0.095, and 0.119 respectively) and 42ug/kg.d for B4 (value of dose: 35, 40, 42, 45ug/kg.d, Z = -3.073, -2.604, -1.773 and -1.603, P = 0.002, 0.008, 0.076 and 0.116 repectively) were the most proper as regard to development of uterine volume.

Conclusion: Karyotype and estrogen dose in HRT affected the uterine response to HRT in girls with TS. The uterine development was positively correlated with estrogen dose in stage B3 and B4 and the value of 22ug/kg.d for B3 and 42ug/kg.d for B4 would be optimal in girls with TS who underwent HRT.

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