ESPE Abstracts (2019) 92 P3-311

Serum Calcium, 25(OH) Vitamin D and Bone Alkaline Phosphatase in Children with Epilepsy Receiving Antiepileptic Drugs in University of Port Harcourt Teaching Hospital

Chidinma Chukwumerije, Iroro Yarhere, Edward Alikor


University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria


Objective: The aim of this study was to analyse bone mineral status in children with epilepsy, on antiepileptic drugs (AEDs) regimen, using serum calcium, 25 (OH) vitamin D and Bone alkaline phosphatase (BALP) and compare these with age and sex matched controls.

Patients and Methods: This was a case - control study, conducted at University of Port Harcourt Teaching Hospital, from September 1 2018 to May 31 2019, with 200 (100 cases and 100 controls) participants, aged 1 - 18 years. Serum calcium, 25 (OH) vitamin D and BALP were analysed in children consecutively recruited using o-Cresolphthalein colorimetry for calcium, ELISA for BALP and 25 (OH) vitamin D. Student's t test was used to compare mean among cases and controls and correlation analysis to test relationships between variables.

Results: Serum calcium and vitamin D were significantly lower in cases, but BALP was higher (P > 0.001). Twenty two percent of cases were below normal vitamin D levels, as against 11% of controls (P = 0.05), while sixty two percent of cases had hypocalcaemia as against 27% of controls (p> 0.001). Cases receiving carbamazepine had lower vitamin D and calcium levels than those receiving phenobarbitone and sodium valproate, but those on sodium valproate had higher BALP. Children on polytherapy had lower vitamin D and calcium but higher BALP levels. Though not significant, there were negative correlations between BALP and vitamin D, but positive correlations between calcium and vitamin D and calcium and BALP

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