The objective of this study has been the analysis of plasma chemistry in a group of children born SGA at the University Hospital of Álava- Txagorritxu and biochemical parameters related to the metabolic syndrome.
Material and Methods: In a cohort of 27 subjects sub (13 boys and 14 girls) from the epiPEG-PreMeb study, a blood sample at 3, 12 and 24 months of life it was extracted. Biochemical parameters s and measured by automated and chemistry levels by ELISA kit (Chemerin human ELISA, Biovendor). The PEG condition was established when the subjects presented a weight or length of at least 2 standard deviations (SD) below, taking as reference the Spanish growth curves (Carrascosa et al., 2010). For strat i fying kind of catch-up, the evolution of weight gain / height for the measurement s was compared: catch-up len t o Δ <0.49 DE, normal Δ 0.5-1 DE and fast Δ> 1 DE. Statistical analysis included the Pearson correlation coefficient or Spearman 's rho, and the distribution of the data was determined by the test of S h apiro - Wilk (SPSS Statistics v24).
Results and Conclusion: Positive correlation was observed between the concentrations of chemerine at 3 months as glucose, triglycerides (TG), insulin, as well as HOMA, and TG and C - reactive protein (CRP) after 24 months. Stratifying by sex, in children positive correlations were found between the chemistry and TG at 3 months and with CRP at 24 months. In girls, the correlation was given with glucose, TG and HOMA at 3 months and with total cholesterol and LDL at 24 months. Regarding the type of catch-up, subjects with slow catch-up presented positive correlation between chemistry at 3 months and TG, insulin and HOMA at that same age. I n who they submitted catch-up normal positive correlation was observed between Concentration of chemistry at 3 months and glycemia at three months and TG concentrations at 24 months. Therefore, by this means, we can conclude that chemistry levels measured at an early age in PEG children could be considered an indicator of future alterations of biochemical parameters related to the metabolic syndrome, especially in cases of slow catch-up
19 - 21 Sep 2019
European Society for Paediatric Endocrinology