hrp0094p2-2 | Adrenals and HPA Axis | ESPE2021

How do urine steroid metabolites of spot samples correlate with 24 hour urine specimens in children with congenital adrenal hyperplasia?

Sommer Grit , Abawi Ozair , Groessl Michael , Halbsguth Ulrike , Charmandari Evangelia , Akker Erika L.T. van den , Fluck Christa E. ,

Introduction: Steroid profiling in children with congenital adrenal hyperplasia (CAH) is used to monitor the balance between androgen and cortisol metabolites and to decide on the optimal glucocorticoid dosage. Twenty-four hour collection is the gold standard for measurement of steroid metabolites in urine, because steroid production follows a circadian rhythm and is influenced by short-term stress and steroid drugs. For some children, e.g. those who were diap...

hrp0094p2-271 | Growth hormone and IGFs | ESPE2021

Linear growth of prepubertal children born small for gestational age on growth hormone therapy for 3 years

Al Shaikh Adnan , Daftardar Hadeer , Aziz Alghamdi Abdul , Jamjoom Majd , Awidah Saniah , Ahmed Mohamed E , Soliman Ashraf ,

Introduction: Recombinant growth hormone (GH) is an effective treatment for short children who are born small for gestational age (SGA). Short children born SGA who fail to demonstrate catch-up growth by 2-4 years of age are candidates for GH treatment initiated to achieve catch-up growth to a normal height in early childhood, maintain a normal height gain throughout childhood, and achieve an adult height within the normal target range. However, some children ...

hrp0094p2-331 | Growth and syndromes (to include Turner syndrome) | ESPE2021

Final and Near-final Adult Height and BMI after Long-term Growth Hormone Treatment in Patients with Turner Syndrome (TS)

Al Shaik Adnan , Daftardar Hadeer , Aziz Alghamdi Abdul , Jamjoom Majd , Awidah Saniah , E Ahmed Mohamed , Soliman Ashraf ,

Objectives: To assess the long-term effect of growth hormone (GH) therapy in children with Turner Syndrome (TS)Patients and methods: We evaluated retrospectively the anthropometric data of 10 girls with TS short children (height SDS <-2) who were diagnosed and treated with GH (0.05 mg/kg/day) between January 2007 till 2018 in our tertiary care center. Before and during GH treatment, auxological and biochemical parameters including He...

hrp0097t11 | Section | ESPE2023

The serum steroid signature of PCOS hints at the involvement of novel pathways for excess androgen biosynthesis

Murat Altinkilic Emre , du Toit Therina , Sakin Onder , Attar Rukset , Grössl Michael , E. Flück Christa

Context: Polycystic ovary syndrome (PCOS) is defined by androgen excess and ovarian dysfunction in the absence of a specific physiological diagnosis. The best clinical marker of androgen excess is hirsutism, while the best biochemical parameter is still a matter of debate. Current consensus guidelines recommend serum free testosterone as the most sensitive serum parameter to measure androgen excess. Recently, however, novel active androgens and androgen metabo...

hrp0097p1-470 | Fat, Metabolism and Obesity | ESPE2023

Evaluation of the Frequency and Time Course of Side Effects Asscociated With Metformin Use In Obese Adolescents As Related to Weight Loss: A Prospective Single-Centre Observational Study

Mısırlı Özdemir Ebru , Dağdeviren Çakır Aydilek , Bilge Özakçe Mehmet , Uçar Ahmet

Background: Metformin is a well-known biguanide approved for treatment of Type2 Diabetes. Metformin is not considered as an anti-obesity drug despite its common off-label use. Currently, there are no data regarding the profile of metformin related gastrointestinal side effects (MRGSE) in obese adolescents.Aim: To identify the frequency and time course of MRGSE in obese adolescents and assess the presence of any associati...

hrp0098fc4.2 | Adrenals and HPA Axis 1 | ESPE2024

11-oxygenated androgens are abundantly produced by first and second-trimester foetal adrenal glands in ex vivo culture

Idkowiak Jan , Melau Cecilie , E Taylow Angela , Juul Anders , T Mitchell Rod , Arlt Wiebke , Jørgensen Anne

Background: Previous descriptions of the steroidogenic capacity of human foetal adrenal glands in an ex vivo culture system focused on the classic androgen pathway and the alternative DHT pathway. However, no information is available on the abundance and role of the adrenal-derived 11-oxygenated androgens during foetal development, and how their levels correlate to classic androgens.Aim: To characterise the ster...

hrp0098p1-40 | Fat, Metabolism and Obesity 1 | ESPE2024

Detection of risk of non-alcoholic hepatic steatosis (nash) in obese children's population through rapid ultrasound measurement of preperitoneral abdominal fat “at the bed side”. a new strategy

Diez-Lopez Ignacio , Maeso Mendez Sandra , Garcia Casares Zuriñe , Calvo Saez Erika , Santos Corraliza Erika , Gamarra Cabrerizo Ainara

NASH is an increasingly relevant finding in the pediatric population affected by obesity. In adults, the evolution of this steatosis towards fibrosis and correlation with metabolic syndrome is increasingly significant. The existence of a rapid and validated in-office screening tool would be very useful.Main Objective: To evaluate whether the measurement of intraperitoneal fat measured through nutritional ultrasound allows for the diagnos...

hrp0098p3-151 | Growth and Syndromes | ESPE2024

Assessment of growth in children with iron deficiency anemia treated with ferrous iron.

Foti Randazzese Simone , Manti Sara , Zirilli Giuseppina , Caim e Flavia , Arcoleo Martina , Gabriela Wasniewska Malgorzata , Valenzise Mariella

Introduction: Iron deficiency anemia is the most common form of anemia in pediatric age. It affects 20.1% of children aged 0-4 years old and 5.9% of children aged 5-14 years old in the Western World with profound implications for the growth. Dietary changes and iron supplementation may be crucial. This study aims to assess the correlation between growth and iron deficiency in children and the effects of ferrous iron treatment on the auxological parameters....

hrp0095p2-3 | Adrenals and HPA Axis | ESPE2022

A Rare Cause of Peripheral Precocious Puberty

Çakır Gündoğan Seçil , Kılınç Uğurlu Aylin , Özdemir Gökçe Ayşe , Özyörük Derya , Yardımcı Gönül , Kasap Yusuf , Karakuş Esra , Sarı Neriman , Seçil Ekşioğlu Ayşe , Ölçücüoğlu Erkan , Boyraz Mehmet

Introduction: Peripheral precocious puberty is a non-gonadotropin-dependent early pubertal development. Exogenous intake of sex steroids, gonadal or adrenal pathologies, ectopic hCG-secreting lesions play a role in the etiology. Adrenal tumors is a rare cause of heterosexual precocious puberty.Case: An eight-year-old female patient was admitted with the complaints of genital hair growth and breast enlargement. The patien...

hrp0095rfc4.5 | Fat, Metabolism and Obesity | ESPE2022

Cerebral perfusion following childhood-onset craniopharyngioma and the relationship with metabolic rate

Elsworth Rebecca L. , Naeem Nimra , Hawton Katherine , Narayan Kruthika , Elson Ruth , Taylor-Miller Tashunka , Lithander Fiona E. , Hamilton-Shield Julian P. , Crowne Elizabeth C. , Hinton Elanor C.

Background: Craniopharyngioma is a non-malignant embryonic tumour in the pituitary-hypothalamic area, associated with hypothalamic obesity. Dysfunctional parasympathetic nervous system activity has been proposed as one mechanism underlying alterations in energy metabolism. Arterial spin labelling (ASL) is a non-invasive MRI technique that quantifies brain tissue perfusion as a proxy for functional activity. Here, we measure cerebral perfusion in patients with ...