hrp0086p1-p734 | Pituitary and Neuroendocrinology P1 | ESPE2016
Marini Romana
, De Pasquale Debora
, Bizzarri Carla
, Santoro Elisa
, Cozza Raffaele
, Cappa Marco
Background: The Adrenocortical Neoplasm (ACN) is a rare condition in childhood (0,3 cases/1000000). In paediatric age, ACN at stage 1 is treated by complete adrenalectomy, while at stages 2 and 3 surgery is followed by adjuvant treatment with Mitotane (M). Chemotherapy is required in metastatic cases (stage 4).Objective and hypotheses: M is an adrenal cytotoxic agent which has both adrenolytic action on ACN cells and inhibition on steroid hormone synthes...