ESPE Abstracts

Background: Patients with vitD resistant rickets (VDRR) due to vitD receptor (VDR) mutations have extreme rickets along with alopesia, severe hypocalcemia, hypophosfatemia secondary to hyperparathroidism and elevated 1,25(OH)2vitD. Although there is no standard therapy for this patients, long-term or intermittanat i.v. or high dose oral calcium suplementations are recommended to correct the hypocalcemia and secondary hyperparathyroidism. ...

Background: Obesity is characterized by insulin resistance of target tissues, such as skeletal muscle, adipose tissue and liver. Skeletal muscle tissue is responsible for approximately 75% of whole body insulin-stimulated glucose uptake. Previously, it has been shown that skeletal muscle strength is significantly associated with insulin resistance in type-2 diabetics and non-diabetics.Objective and hypotheses: To examine the relationship between insulin ...

Introduction: Autoimmune polyendocrinopathy type 1, or APECED syndrome (Autoimmune Polyendocrinopathy Candidiasis EctodermalDystrophy), is a genetic disease with a juvenile onset, associating chronic mucocutaneous candidiasis, hypoparathyroidism and adrenal insufficiency of autoimmune origin. It is a rare disease, more common in certain populations due to inbreeding or a founder effect such as in Finland where its prevalence has been estimated at 1/25,000....