hrp0084p1-125 | Thyroid | ESPE2015
Ghaddhab Chiraz
, Van Den Eeckhaute Emmanuel
, Hancisse Olivier
, Driessens Natacha
, Versteyhe Soetkin
, Miot Francoise
, Dumont Jacques-Emile
, Corvilain Bernard
Background: H2O2 produced in large quantities in the thyroid may play a role in the pathogenesis of thyroid nodules and cancer. In vitro, moderate amounts of H2O2 are able to cause similar DNA damage compared to irradiation and even to induce RET/PTC rearrangements.Objective and hypotheses: We compared the defence mechanisms against H2O2 and irradiation in human thyrocytes, T-cell...