hrp0089p2-p284 | Multisystem Endocrine Disorders P2 | ESPE2018

Endocrine and Metabolic Complications in Children and Adolescents with Sickle Cell Disease: An Italian Cohort Study

Bigi Elena , Bruzzi Patrizia , Palazzi Giovanni , Predieri Barbara , Lucaccioni Laura , Pancaldi Alessia , Lodi Mariachiara , Cellini Monica , Iughetti Lorenzo

Background: Children with Sickle Cell Disease (SCD) show endocrine complications and metabolic alterations. The physiopathology of these conditions is not completely understood: iron overload due to chronic transfusions, ischemic damage, and inflammatory state related to vaso-occlusive crises may be involved. Aims of this study were to evaluate the growth pattern and the endocrine and metabolic alterations in a cohort of children with SCD and to detect the relationship between...