hrp0095p1-501 | GH and IGFs | ESPE2022

IGFBP-3 assessment in the work-up of short stature

DeodatiAnnalisa , Inzaghi Elena , Elisa Amodeo Maria , Cianfarani Stefano

Background: The diagnosis of GH deficiency (GHD) is not straightforward in childhood and adolescence, requiring comprehensive clinical, anthropometric, biochemical, endocrine, and neuroradiological assessment. Although pharmacological GH stimulation tests are still considered the gold standard for GHD diagnosis, they are burdened by both poor specificity and side effects. Several studies have addressed the issue of sensitivity and specificity of IGFBP-3 assess...