ESPE2014 Poster Category 2 Diabetes (2) (22 abstracts)
Early Detection and Treatment of Cystic Fibrosis Related Diabetes Mellitus in a Tertiary Paediatric Centre: a Case Series
Eirin Carolan a , Claire Murphy a , Caoimhe Howard a , Dubhfeasa Slattery b , Fiona Healy b , Ciara Mc Donnell a & Nuala Murphy a
aDepartment of Diabetes and Endocrinology, Children’s University Hospital, Temple Street, Dublin 1, Ireland; bDepartment of Respiratory Medicine, Children’s University Hospital, Temple Street, Dublin 1, Ireland
Background: Early recognition and treatment of cystic fibrosis related diabetes (CFRD) significantly improves respiratory and nutritional status of patients with cystic fibrosis (CF). American Diabetes Association (ADA) guidelines recommend annual screening with oral glucose tolerance test (OGTT) for all affected children from age 10 years.
Objective and hypothesis: We sought to determine if screening for CFRD was optimal and to determine if early treatment of CFRD improved respiratory and nutritional outcomes.
Methods: We retrospectively reviewed laboratory data for all CF patients >10 years and medical records of patients where OGTT was abnormal.
Results: Ninety-six CF patients aged 8.53±4.7 years attend our centre. All 47 patients (49% of total CF population) aged >10 years had annual OGTT. CFRD was diagnosed in 6 (6.3%) patients, two following lung transplantation. Four (4.1%) patients had impaired glucose tolerance and 1 (1%) had indeterminate glycaemia. Mean age at diagnosis of CFRD was 12.7±2.8 years. Mean HbA1c at diagnosis of CFRD was 55.5±22.2 mmol/mol, however two patients had normal HbA1c values. All patients were managed with subcutaneous insulin analogues. Predicted FEV1 values increased by 6±4.3% and BMI by 1.85±0.35 kg/m2 in CFRD patients 1 year post commencement of insulin therapy.
Conclusion: Early detection of CFRD allows prompt treatment and is associated with improved respiratory and nutritional outcomes.
Article tools
My recent searches
My recently viewed abstracts
ESPE Abstracts
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more