ESPE Abstracts

ESPE Abstracts

Published by BioScientifica
Volume 82 | ESPE2014 | Next issue

53rd Annual ESPE (ESPE 2014)

Dublin, Ireland
18 Sep 2014 - 20 Sep 2014

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Dublin, Ireland; 18-20 September 2014. Further information

Poster Category 3

Growth (3)

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Growth (2)
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Growth (4)

hrp0082p3-d2-849 | Growth (3) | ESPE2014

GH Therapy in Prepubertal Children: Results After 4 Years

Galesanu Corina , Loghin Andra Iulia , Grozavu Ilinka , Apostu Luminita , Ungureanu Didona , Galesanu Mihail Romeo

Background: GH therapy is being used worldwide to improve height outcome in children with GH deficiency (GHD), with minimal serious side effects. Early diagnosis and therapy initiation optimize growth outcomes.Objectives: To evaluate growth and safety during the first 4 years of GH treatment in 33 GHD children.Methods: We reviewed clinical data of 33 prepubertal children (23 boys and ten girls): 30 with isolated GH deficiency (IGHD...
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hrp0082p3-d2-850 | Growth (3) | ESPE2014

A Follow-up Study up to Adult Height of the Patients Included in the Phase iii Clinical Trial with the Biosimilar Human Recombinant GH (omnitrope®) on the Treatment of Spanish Children with GH Deficit

Borras Victoria , Siguero Juan Pedro Lopez , Martinez Gabriela , Corripio Raquel , Fernanadez Juan , Labarta Jose , Ferrer Marta , Cabrinety Nuria , Prieto Pablo , Ramon Marta , Bosch Jordi , Espino Rafael , Garcia Margarida Palla

Introduction: The results of the phase III clinical trial that evaluated the efficacy and safety of the biosimilar recombinant human GH - rhGH - (Omnitrope®, Sandoz) on the treatment of Spanish children with GH deficiency were published in 2011. At the end of the study those patients that were still growing remained on treatment within the usual clinical practice.Objective: To know the values of adult height of the children who participat...
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hrp0082p3-d2-851 | Growth (3) | ESPE2014

Growth pattern of the nigerian child compared to international references

Elusiyan Jerome , Ibekwe MaryAnn Ugochi , Alkali Y , Agwu J. Chizo

Background: There are currently no specific growth charts for use in Nigerian children over the age of 5 years. Health workers rely on charts developed by the Center for Disease Control for children in USA (2000CDC US) or the UK 1990 growth charts for British children. It is unknown whether Nigerian children grow to the same height or at the same tempo as American or British children.Objective and hypotheses: To compare the growth of the Nigerian child t...
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hrp0082p3-d2-852 | Growth (3) | ESPE2014

Evaluation of Potential Waste of GH Across Available GH Pen Devices and an Electronic GH Delivery Device

Locklear JC , Edwards NC , Phillips AL

Background: Several somatropin products are available as pen and electronic devices. When administering the last dose from a device, patients may have an insufficient amount of GH remaining for a full dose.Objective and hypotheses: The aim of this analysis was to estimate the potential GH waste per patient with pen devices and the easypod® device, and to quantify the potential economic impact of expected GH waste from patient and health c...
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hrp0082p3-d2-853 | Growth (3) | ESPE2014

Switching From the Original to the Biosimilar Recombinant Human GH – Omnitrope®: an Experience of a Single Paediatric Centre in Spain

Gila Ana Gomez , Garcia Margarida Palla

Introduction: In 2009/2010 Hospital Virgen del Rocío, Seville, Spain changed the treatment of patients with GH deficiency (GHD) from various original recombinant human GH (rhGH) to a biosimilar rhGh (Omnitrope®, Sandoz).Objective: To evaluate the consequences on growth parameters of switching treatment, from original rhGHs to Omnitrope® in children with GHD, in a window period of 36 months.Metho...
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hrp0082p3-d2-854 | Growth (3) | ESPE2014

Descriptive Analysis of Medication Adherence for Patients Treated with GH Therapy

Michels S L , Uribe C , Li Y , Meletiche D M , Velez F F , Locklear J C

Background: GH deficiency (GHD) occurs in one in 4000–one in 10 000 children, but can also be diagnosed in adults.1 GHD therapy typically requires injections over a period of years.2 Adherence to long-term GHT presents a challenge.Objective and hypotheses: This study describes the rates of adherence to GHT among patients with GHD.Method: Members who were continuously enrolled 6 months pre- and 12 months p...
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hrp0082p3-d2-855 | Growth (3) | ESPE2014

Effect of Cyanotic and Acyanotic Congenital Heart Disease on Placental and Birth Size

Soliman Ashraf , Shatlah Emad , Sabt Aml , Alyafei Fawzia , Alqadi Mohanad

Background: Abnormal cardiac development leading to CHD can be associated with abnormal placental development with abnormal trophoblast invasion and remodeling resulting in abnormal transfer of nutrients and oxygen.Objective and hypotheses: We measured the anthropometric parameters (length, weight, and head circumference) and the placental weight of 49 FT newborns (gestation period >36 weeks) infants with CHD ((cyanotic (n=8) and acyanotic (...
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hrp0082p3-d2-856 | Growth (3) | ESPE2014

Anthropometric Evaluation of a Cohort of School-Aged Children: the Need for National Growth References in Romania

Pop Raluca-Monica , Pascanu Ionela , Pop Marian

Background: For children above 5 years of age no specific national growth charts are available in our country, the most widely used being the Swiss ones (Prader, 1989). Previous studies have shown significant differences between the various international standards available regarding. The incidence of growth disorders.Objective and hypotheses: Our aim was to compare the recommended growth reference with a new one based on a national representative sample...
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hrp0082p3-d2-857 | Growth (3) | ESPE2014

Differences in Personality of Monozygotic Twins can be Predicted by Difference in Birth Weight in Teen Monozygotic Twins

Wimmer Lioba , Woelfle Joachim , Bartmann Peter , Schulte Sandra , Gohlke Bettina

Background: Low birth weight and unfavourable intrauterine conditions are associated with long-term effects on life. The influence of intrauterine conditions on personality might be underestimated.Objective and hypotheses: In a longitudinal study we followed genetically identical twins with intra-twin birth-weight (bw) differences due to twin–twin transfusion syndrome (ttts) from birth until puberty.Method: 23 pairs of monozyg...
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hrp0082p3-d2-858 | Growth (3) | ESPE2014

The Growth Speed of Late Pretem Infants Aged 1 Year

Qian Cheng

Background and aims: The physical growth of late preterm infants (LPI) is unknown, to investigate the growth of LPIs to provide the basis for growth evaluation of LPI.Methods: Infants were recruited for a cohort study in Department of Primary Child Health Care, Children’s Hospital, Chongqing Medical University from May 2010 to November 2011. LPI and full term infants (FTI) were compared in terms of weight for age Z-scores (WAZ), length for ...
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hrp0082p3-d2-859 | Growth (3) | ESPE2014

Response of GH Therapy in Six Children with Achondroplasia

Kim Yoon Jung , Cho Byung Wook , Kim Ji Yoon , Kim Heung Sik , Lee Hee Jung

Background: Achondroplasia is the most common condition characterized by disproportionate short stature. Patients with achondroplasia progressively fall below normal standards for length and height. GH has been widely used to treat short stature with or without GH deficiency (GHD).Objective and hypotheses: The purpose of the present study was to clarify the effectiveness of GH therapy on short stature in achondroplasia.Method: The ...
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hrp0082p3-d2-860 | Growth (3) | ESPE2014

Clinical Expression of Familial Williams–Beuren Syndrome in a Turkish Family

Parlak Mesut , Nur Banu Guzel , Mihci Ercan , Durmaz Erdem , Karauzum Sibel Berker , Akcurin Sema , Bircan Iffet

Background: WBS is a rare genetic disorder characterized by distinctive facial features, intellectual disability, cardiovascular anomalies, and infantile hypercalcemia.Objective and hypotheses: Majority of WBS cases occur sporadically, only five families with clinically confirmed WBS have been identified by molecular cytogenetic analysis. Here, we report on the three molecular cytogenetically confirmed familial WBS detected in a family with familial shor...
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hrp0082p3-d2-861 | Growth (3) | ESPE2014

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