Volume 82 | ESPE2014 | Next issue

ESPE 2014

Dublin, Ireland
18 Sep 2014 - 20 Sep 2014

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Dublin, Ireland; 18-20 September 2014. Further information

Poster Category 2

Growth (1)

hrp0082p2-d2-461 | Growth (1) | ESPE2014

Anophthalmia, Abnormal Pituitary Development, and Suboptimal Response to GH Therapy in Two Children With Microdeletions of 14q22q23

Dusatkova Petra , Slamova Zuzana , Sumnik Zdenek , Simandlova Martina , Zemankova Elsa , Sedlacek Zdenek , Lebl Jan

Background: Microdeletions of 14q22q23 have been associated with eye abnormalities. Other symptoms in deletion carriers are less well recognized.Objective and hypotheses: We focused on growth characteristics and response to GH treatment in two unrelated children with 14q22q23 deletions.Method: Array comparative genomic hybridisation (aCGH).Results: Both patients displayed bilateral anophthalmia. Their brain M...

hrp0082p2-d2-462 | Growth (1) | ESPE2014

Adiponectin Levels as Early Marker of Insulin Resistance in Children Born Small for Gestational Age in Our Cohort

Yadav Sangita , Gupta Ainam , Ramji Siddharth , Mishra T K

Background: Small for gestational age (SGA) children, especially those with postnatal catchup growth, have increased risk of insulin resistance and adult metabolic diseases. Adipokines produced by adipose tissue play crucial role in fetal growth and early postnatal life. Low adiponectin (adipokine) is marker of insulin resistance.Objective: To evaluate adiponectin levels in term SGA at 15–18 months age and its relationship with postnatal catchup gro...

hrp0082p2-d2-463 | Growth (1) | ESPE2014

Recombinant Human GH Effects on Growth and Clinical Status in Cystic Fibrosis

Ghergherehchi Robabeh , Rafeey Mandana , Habibzadeh Afshin , Zamani Masoud , Ansarin Khalil , Shabestari Mahnaz Sadeghi

Background: Growth retardation is a common finding in cystic fibrosis (CF) patients. Recombinant human GH (rhGH) has shown promising results in improving weight, height and clinical status of CF patients.Objective and hypotheses: In this study we aim to evaluate efficacy of rhGH on growth and clinical status in CF patients.Method: In this prospective clinical trial we recruited 34 CF patients (58.8% male with mean age of 62.05&#177...

hrp0082p2-d2-464 | Growth (1) | ESPE2014

Interrelationships Between BMI and Other Overweight Related Anthropometric Variables in Childhood

Brannsether Bente , Eide Geir Egil , Roelants Mathieu , Bjerknes Robert , Juliusson Petur Benedikt

Background: Anthropometry is the general tool for defining overweight and obesity, with BMI cut-offs adjusted for sex and age, as the most commonly used variable in childhood.Objective and hypotheses: Based on the interrelationships between BMI and different overweight-related anthropometric variables we wanted to find out which anthropometric variables contribute most to the variation in BMI, and how age affect this picture?Method...

hrp0082p2-d2-465 | Growth (1) | ESPE2014

Assessment of Omentin-1, Vaspin, and Visfatin Levels in Pediatric Patients with GH Deficiency

Sawicka Beata , Borysewicz-Sanczyk Hanna , Zasim Aneta , Jakubowska Ewa , Bossowski Artur

Introduction: GH deficiency (GHD) is a disease, in which the pituitary gland does not produce enough GH. GHD has a variety of different negative effects at different ages; e.g. it can result short stature and increased adiposity. Excessive intra-abdominal fat is associated with an increased risk of cardiovascular disease. In recent years new adipokines such as:omentin-1, vaspin, and visfatin have been described. Omentin-1 is decreased in obesity in contrast to increased vaspin...

hrp0082p2-d2-466 | Growth (1) | ESPE2014

Normal Growth in Aromatase Excess Syndrome by Pharmacological Inhibition of Aromatase Activity

Deubzer Beate , Binder Gerhard

Introduction: In the rare aromatase excess syndrome aromatase turnover from androgens to estrogens is constitutively increased. Affected males show signs of hyperestrogenism such as feminization (particularly gynecomastia), hypogonadism, and short adult height due to early epiphyseal closure.Case report: Here, we report the different statural growth of two first degree cousins affected by aromatase excess syndrome. Both carried the same heterozygote dele...

hrp0082p2-d2-467 | Growth (1) | ESPE2014

The Effect of the Environmental Factors on Growth Pattern of Turkish Children Having the Same Genetic Origin

Yuca Sevil Ari , Cesur Yasar , Kurtoglu Selim , Mazicioglu Mumtaz Mustafa , Cimbek Emine Ayca

Background: Childhood is a dynamic process with continuous growth and development. Growth charts are essential for the assessment of children’s health status. Standards previously established in children aged 6–18 years, according to percentile curves are used in Turkey.Objective and hypotheses: To determine the effect of different environmental factors on growth of children with the same genetic origin. We investigated the parameters of growth...

hrp0082p2-d2-468 | Growth (1) | ESPE2014

Successful GH Treatment for Severe Growth Failure in Paediatric Patients with Anorexia Nervosa

Fjellestad-Paulsen Anne , Bargiacchi Anne , Doyen Catherine , Raverdy Cecile , Carel Jean-Claude , Leheuzey Marie-France , Leger Juliane

Background: Anorexia nervosa (AN), a state of chronic nutritional deprivation prevalent in children and young adolescents, is associated with major changes to the hypothalamic–pituitary axis including the GH–IGF1 axis, thyroid function, hypercortisolemia, and hypogonadotropic–hypogonadism, with delayed puberty and a low growth velocity (GV) at a time critical for the pubertal growth spurt, potentially affecting adult height. The effects of supraphysiological hum...

hrp0082p2-d2-469 | Growth (1) | ESPE2014

The Analysis of Limb Segments Length and Body Proportion of Children and Adolescents Aged 6–17 Years in the Main Urban Area of Chongqing

Jiao Yanhua , Zhu Min , Xiong Feng

Objective: To accumulate the information in the long-term studies of the variation of the limb segments length and proportion in the process of growth and development of children, we have measured and summarized the average level of limb segments length for the children and adolescents in the main urban area of Chongqing, calculated the ratios of limb segments length to height and extremities-trunk ratio, body proportions, and analyze their age trends.Me...

hrp0082p2-d2-470 | Growth (1) | ESPE2014

Severe Short Stature due to a Heterozygous igf1r Mutation With a Good Response to rhgh Therapy: a Family Study

Borras-Perez Victoria , Fernandez-Cancio Monica , Gomez-Nunez Ana , Catala-Puigbo M , Audi Laura , Campos-Barros Angel

Background: IGF1 resistance syndrome (IGF1RS) is characterized by intrauterine and postnatal growth deficit with normal or supranormal IGF1 levels. Additional features may include intellectual deficit, microcephaly, and dysmorphisms. IGF1RS may be caused by genomic or genetic defects affecting the IGF1R locus (15q26.3).Objective and hypotheses: Case report: a girl born at 36.5 weeks, BW 1.935 g (−3.2 SDS), length 41 cm (−4.4 SDS) and...

hrp0082p2-d2-471 | Growth (1) | ESPE2014

When and Why Should We Investigate the SRCAP Gene in Cases of Short Stature?

Lucas Luiza Silveira , Boycott Kym M , Nikkel Sarah M , Lucas Elizabeth Lemos Silveira

Background: The heterozygous mutation in the SRCAP gene (611421) on chromosome 16p11.2 causes a rare genetic disorder named Floating–Harbor syndrome (FHS). The clinical diagnosis of FHS is characterized by a triad of short stature with significantly delayed bone age; expressive language delay, usually in the presence of normal motor development; and a triangular face with prominent nose and deep-set eyes.Objective: To investigate the presence of SRC...

hrp0082p2-d2-472 | Growth (1) | ESPE2014

Body Proportions Estimated by Photometry

Gerver Willem Jan , Brecheisen Ralph , Penders Bas , Straetemans Saartje

Background: The growth process that transforms a newborn into an adult implies that there is not only an increase in height but above all a constant change in body proportions. Knowledge of the body proportions gives insight into the natural process of maturation and any disturbance can be used as a diagnostic tool.Objective and hypotheses: Manual measurement of body dimensions is a highly time-consuming procedure requiring a variety of measurement tools...

hrp0082p2-d2-473 | Growth (1) | ESPE2014

GH Deficiency in a Child With De Novo 2q31.1 Microdeletion

Kaloumenou Irene , Karachaliou Feneli , Vlachopapadopoulou Elpis-Athina , Fotinou Aspasia , Michalacos Stefanos

Background: The clinical phenotype of the chromosome 2q31 deletion syndrome consists of a variety of limb abnormalities and other skeletal defects, craniofacial dysmorhic features, developmental delay, and other not specific congenital anomalies.Objective and hypotheses: To describe a patient with 2q31.1 microdeletion syndrome and short stature, diagnosed with GH deficiency.Method: We describe a 5 years and 4 months girl with devel...