Objective: Platelets play a key role in the development and progression of cardiovascular disease. The degree of platelet activation may be assessed by platelet indices such as platelet count, mean platelet volume (MPV) and platelet distribution width (PDW). In addition, both epidemiological and in-vitro studies have linked vitamin D deficiency to enigmatic disease including cardiovascular disease however a clear mechanistic link remains missing. In present study, we aimed to evaluate the relationship between mean platelet volume which sometimes has been suggested to be a biological marker of cardiovascular disease especially coronary arterial disease and vitamin D levels.
Methods: In present study, a total of 484 children with vitamin D deficiency or insufficiency and 200 children as control were enrolled the study. The vitamin D deficiency and insufficiency group were divided in two groups (Group 1; children who had a vitamin D levels below 20 ng/ml; group 2; children who had a vitamin D levels between 20 and 30 ng/ml). All the children in control group had a vitamin D level above 30 ng/ml). The hemogram and MPV values were compared in these three group.
Results: We did not find any statistically significant difference between group with regard to age and gender. The mean MPV values were found to be 7.95±0.95 fL in group 1, 7.96±1.03 fL in group 2, 7.89±1.23 fL in control. No statistically significant difference was found with regard to MPV values and also no statistically significant correlation was found between vitamin D and MPV values (r:−0.48, P>0.05).
Conclusion: Due to observation of no changing in MPV values according to different vitamin D levels, we concluded that MPV might not play a role in vitamin D associated cardiovascular disease. But for certainly definition further large studies are needed.
20 - 22 Sep 2014
European Society for Paediatric Endocrinology