ESPE Abstracts (2014) 82 P-D-2-3-389

Type and Time of Feeding in the First Year of Life are Not Associated to Circulating Multimeric Adiponectin Levels in Obese Children

Simonetta Bellonea, Flavia Prodama,b, Letizia Trovatoa, Marta Roccioa, Agostina Maroldaa, Cristina Fioritoa, Enza Giglionea & Gianni Bonaa

aDivision of Pediatrics, University of Piemonte Orientale, Novara, Italy; bEndocrinology, University of Piemonte Orientale, Novara, Italy

Background: Nutrition and growth in the postnatal phase seems to have an important role for the future risk of obesity, type 2 diabetes, and cardiovascular diseases. It has been suggested that circulating levels of adiponectin in the first 2 years of life are influenced by type of feeding in small for gestational age.

Objective and hypotheses: Aim of our study was to evaluate if total and multimeric adiponectin levels in obese adequate for gestational age (AGA) children could be influenced by type and time of feeding in the first year of life.

Method: 112 obese children and adolescent (BMI classification by IOFT), born AGA, underwent a clinical and metabolic evaluation, included OGTT. They have been divided in three groups based on type of feeding in the first year of life: group 1 (prolonged breastfeeding, >6 months; 41 subjects); group 2 short breastfeeding, 2–6 months; 37 subjects); group 3 (formula feeding since the first 15 days of life; 35 subjects). Total, high (HMV) and medium (MMV) molecular weight adiponectin levels have been measured.

Results: Auxological parameters were similar among the three groups. Nor metabolic differences nor differences in circulating levels of different adiponectin isoforms have been found, not even when data are corrected by sex and pubertal stage. Instead, HMV adiponectin levels were differently distributed by sex and pubertal stage, being lower in males compared to females starting from puberty, independently by BMI–SDS (P<0.02). Total, HMV and MMV adiponectin levels did not correlate to clinical parameters at birth, time of feeding or weaning.

Conclusion: In pediatric obesity adiponectin secretion seems not to be influenced by type of feeding in the first year of life, while demonstrate a different regulation by sex and puberty. Other nutritional factors in the short period could have a role in adiponectin regulation and should be investigated.

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