ESPE Abstracts (2014) 82 P-D-3-2-741

Incidence of Dyslipidemia and its Association with Glycemic Control in Adolescents and Young Adults with Type 1 Diabetes

Shin-Hee Kim, In-Ah Jung, Won Kyoung Cho, Kyoung Soon Cho, So Hyun Park, Min Ho Jung & Byoung Kyu Suh

Department of Pediatrics, The Catholic University of Korea School of Medicine, Seoul, Republic of Korea

Background: Hyperglycemia and dyslipidemia are metabolic abnormalities commonly found in type 1 diabetes.

Objective and hypotheses: Limited data are available on the relationship between glycemic control and dyslipidemia in patients with type 1 diabetes. We aimed to investigate the incidence of dyslipidemia and its association with glycemic control in adolescents and young adults with type 1 diabetes.

Method: This cross-sectional study included 29 Korean patients with type 1 diabetes aged 10–25 years. Eighteen (62%) patients were female and median duration of diabetes was 7.5 years (range: 0.2–15.6). We compared the lipid profiles of patients with dyslipidemia and those of patients without dyslipidemia. In addition, correlations between HbA1c and lipid profiles (total cholesterol (TC); LDL cholesterol (LDL-C); HDL cholesterol (HDL-C); and triglyceride (TG)) were determined by linear regression analysis.

Results: Of 29 patients with type 1 diabetes, 11 (38%) had dyslipidemia. There were no statistically significant differences between dyslipidemia and non-dyslipidemia group regarding age, duration of illness, and microalbuminuria. HbA1c level was positively correlated with TC (P=0.03; R2=0.395) and TG (P=0.005; R2=0.51). Patients with dyslipidemia were more likely to have the higher median values of HbA1c than those without dyslipidemia (9.2% (range: 7.5–13.3) vs 7.9% (range: 6.6–10.8); P=0.002). Patients with dyslipidemia were more likely to have the higher median values of BMI z-score than those without dyslipidemia (0.7 (range: −0.57 to 2.6) vs −0.4 (range: −2.5 to 2.2); P=0.02). There were no differences among the groups with respect to age, disease duration.

Conclusion: A substantial proportion of adolescents and young adults with type 1 diabetes had dyslipidemia. We found a correlation between poor glycemic control and poor lipid profiles in young patients with type 1 diabetes.

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