Aims: Comparison of perinatal outcomes and thyroid status of newborns from women with Hashimoto thyroiditis (HT) in depending on indemnification of hypothyroidism in 1st trimester of pregnancy.
Methods: 43 newborns have been divided into two groups where 1st group was newborns from mothers with non-compensated HT in 1st trimester of pregnancy, n=27; 2nd group newborns from mothers, compensated in 1st trimester, n=16. The health estimation was spent on a scale of Apgar. TTG, T3, T4, Ab-TPO was defined in blood serum by radioimmune methods.
Results: In 1st group authentically smaller number of children were born in time (P<0.05), and 4 (14.8%) functionally unripe. In 1st group of an estimation of newborns on scale Apgar on 1st and 5th minutes (6.19±0.15 and 7.15±0.15) were low, than in 2nd group (6.81±0.14 and 7.69±0.12 (P<0.01)). At newborns of 1st group it was more often observed easy intrauterine asphyxia (63%), and only in this group 1 child was born with average asphyxia. Only in this group at 9 (33.33%) newborns are diagnosed cases of a long current of the icteric period. At newborns of 1st group levels of TTG and Ab-TPO were authentically above, T3 and T4 more low, than in 2nd group (P<0.001). Newborns from mothers with late compensated HT with high level Ab-TPO in 3.6 times is more often were born, 44.4%(12) had neonatal transitory hypothyroidism, 7.41%(2) congenital hypothyroidism.
Conclusions: Adequate indemnification of HT in early pregnancy is very important.
20 - 22 Sep 2014
European Society for Paediatric Endocrinology