ESPE Abstracts (2014) 82 P-D-3-2-998

Importance of Early Indemnification of Hashimoto Thyroiditis at Pregnant Women in Conditions of Iodine Deficiency in Republic of Uzbekistan

Sakhlo Muratova

Republican Scientifically – Practical Medical Centre of Endocrinology, Tashkent, Uzbekistan

Aims: Comparison of perinatal outcomes and thyroid status of newborns from women with Hashimoto thyroiditis (HT) in depending on indemnification of hypothyroidism in 1st trimester of pregnancy.

Methods: 43 newborns have been divided into two groups where 1st group was newborns from mothers with non-compensated HT in 1st trimester of pregnancy, n=27; 2nd group – newborns from mothers, compensated in 1st trimester, n=16. The health estimation was spent on a scale of Apgar. TTG, T3, T4, Ab-TPO was defined in blood serum by radioimmune methods.

Results: In 1st group authentically smaller number of children were born in time (P<0.05), and 4 (14.8%) – functionally unripe. In 1st group of an estimation of newborns on scale Apgar on 1st and 5th minutes (6.19±0.15 and 7.15±0.15) were low, than in 2nd group (6.81±0.14 and 7.69±0.12 (P<0.01)). At newborns of 1st group it was more often observed easy intrauterine asphyxia (63%), and only in this group 1 child was born with average asphyxia. Only in this group at 9 (33.33%) newborns are diagnosed cases of a long current of the icteric period. At newborns of 1st group levels of TTG and Ab-TPO were authentically above, T3 and T4 – more low, than in 2nd group (P<0.001). Newborns from mothers with late compensated HT with high level Ab-TPO in 3.6 times is more often were born, 44.4%(12) had neonatal transitory hypothyroidism, 7.41%(2) – congenital hypothyroidism.

Conclusions: Adequate indemnification of HT in early pregnancy is very important.

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