ESPE Abstracts (2014) 82 P-D-3-3-799

Gonads and Gynaecology

Effects of GNRH Analogue Treatment on Internal Genitales of Girls with Central Precocious

Havva Nur Peltek Kendirci, Zehra Aycan, Elif Sagsak & Yasemin Tasci Yildiz

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Dr. Sami Ulus Women Health, Children’s Training and Research Hospital, Ankara, Turkey


Background: The GnRH analoques have been used to treat many diverse reproductive system disorders, including precocious puberty.

Objective and hypotheses: The present study aims to investigate the effects of GnRH analogue (GnRHa) treatment on internal genitales of girls with central precocious puberty (CPP).

Method: The study included 40 girls who were diagnosed as CPP and treated with GnRH analogue (leuprolide acetate, Lucrin depot®. 3.75 mg of i.m. or s.c. injections once every 28 days). Patients’ age, bone age, puberty stage, LH, FSH and estradiol levels were noted retrospectively. Ovarian and uterin volumes were calculated in both initial and post-treatment ultrasounds, uterin corpus/cervix differentiation, endometrium and follicules presence were evaluated. Values before and after therapy were compared.

Results: Chronological ages of forty girls with CPP was 8.0±1.2, bone age was 9.7±1.8. They were treated with GnRH analogue for 13.6±2.0 (12–18) months. Basal LH, FSH and estradiol levels and puberty stages after therapy decreased significantly compared with the initial values (P=0.00). Inıtial mean ovarian volume was 2.4±2.1 cm3 and regressed to 1.6±1.1 cm3 and uterin volume regressed from 4.9±4.9 to 3.6±3.7 cm3 after treatment (P=0.01, P=0.00 respectively). Endometrial thickening existed at 30% of patients and uterin corpus- cervix differentiation at 25% initially and regressed to 12.5% ve 7.5% respectively, and it was statistically significant (P=0.01). It is observed that number and sizes of ovarian follicules decreased significantly (P=0.01).

Conclusion: GnRH analogue treatment regresses puberty stage by repressing gonadothropin levels, and also decrease uterin and ovarian sizes, regresses uterin pubertal alterations and decreases number and sizes of ovarian follicules.

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