ESPE2015 Poster Category 2 Gonads (14 abstracts)
The Effect and Pharmacokinetics of Percutaneous Administration of Dihydrotestosterone Gel in Chinese Children with Microphallus
Zhang Jun , Chen Qiuli , Guo Song , Du Minlian , Li Yanhong , Ma Huamei & Chen Hongshan
Hospital of Sun Yat-Sen University, Guangzhou, China
Background: Percutaneous administration of dihydrotestosterone (DHT) gel has been successful used in promoting phallic growth in children with micropenis. We investigated whether percutaneous administration of DHT gel is similarly effective in Chinese children with microphallus due to various etiologies.
Objective and hypotheses: To study the pharmacokinetics and effect of percutaneous administration DHT gel in the Chinese microphallus patients.
Method: 14 patients (age range 1.45–8.47 years) with microphallus of miscellaneous etiologies were studied prospectively. 2.5% DHT gel was applied to the phallus once daily at a dose of 0.3–0.4 mg/kg body weight. Serum DHT concentrations were measured at 0, 2, 4, 8, 12 and 24 h following application of DHT gel.
Results: Peak DHT concentrations were attained within 2–12 h after application of the gel and subsequently remained within the pre-adolescence range in all but one patient, who remains consistently high level. An increase in phallic growth, ranging from 0.2–1.7 cm in lehgth, 0.1–2 cm in width, and 0.3–1 cm in circumstance was achieved after 3–4 months of treatment in all patients whose DHT concentrations were maintained within pre-adolescence range.
Conclusion: Percutaneous administration of DHT in a dose of 0.3–0.4 mg/kg once daily for a period of 3–4 months may be useful in the management of patients with testosterone biosynthetic defects in Chinese patients with micropenis prior to reconstructive surgery.
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