ESPE Abstracts

Aim: To study incidence and risk factors of diabetic nephropathy (DN) in children and adolescents as per the Republic of Uzbekistan National Register.

Method: An information list (card) and appropriate software were developed on the basis of the DN register. The cards were collected in every region of Uzbekistan to be introduced into a computer database.

Results: DN screening performed in children by Alikhanova N M in 1998 showed that 4+5 degree DN incidence in children and adolescents was 20.4 and 51% respectively. In 2007 on the basis of specially developed register card data on incidence of DN in children and adolescents with one type diabetes mellitus was assessed in the Republic of Uzbekistan. four and five degree DN incidence in children was found 17.0 and 0.6%, to be 31.7% in adolescents and lower than the one in 1998, but higher that the one in the 2006-year Register. It was 11.2 and 20.7% respectively, to show that there is 1.5–time difference between actual and registered DN incidence. Inheritability by diabetes mellitus and by arterial pressure, mean daily hyperglycaemia, increase in HbA1c, body mass and cholesterol, reduction of blood fibrinolytic activity and both daily and nocturnal increase in arterial pressure as well as growth in manifestations of autonomic neuropathy are among the risk factors of onset and progression of DN in children and adolescents. Cow milk feeding, low weight at birth and disease duration differed insignificantly.

Conclusions: Rate of registration of late diabetic complications, DN and chronic renal insufficiency (CRI) in particular remains low, though in 50% and 100% children and adolescents respectively, CRI is the main cause of death.