ESPE Abstracts (2015) 84 P-3-991

ESPE2015 Poster Category 3 Gonads (23 abstracts)

Pelvic MRI as Alternative to Pelvic us for the Diagnosis of PCOS in Overweight and Obese Adolescent Girls

Simon Kayemba-Kay a, , Anne Heron b & Sidi Mohamed Benosman c


aPaediatric Endocrinology Unit, Department of Paediatrics & Neonatal Medicine, Victor Jousselin Hospital, Dreux, France; bClinical Research Unit, Victor Jousselin Hospital, Dreux, France; cRadiology Department, Victor Jousselin Hospital, Dreux, France


Background: Polycystic ovary syndrome (PCOS) is a common reproductive endocrinopathy in women of childbearing age, affecting 5–10% women in this age group. Its suggestive cardinal features are hyperandrogenism, ovulatory dysfunction and/or polycystic ovary appearance. The diagnostic gold standard tool is pelvic ultrasound (PUS) which may be limited in overweight and obese adolescent girls.

Objective and hypotheses: To evaluate the contribution of pelvic MRI in diagnosis of PCOS in overweight and obese adolescent girls.

Method: Six adolescent girls seen for signs and symptoms of hyperandrogenism and menstrual irregularity were biochemically screened (LH, FSH, testosterone, S-DHEA, Δ4 androstenedione, 17(OH) P, SHBG, TSH, fT4 and lipid profile, fasting blood sugar and HOMA IR and HOMA-B). Each had PUS and/or pelvic MRI (PMRI) performed. Other causes of hyperandrogenism were excluded.

Imaging: PUS performed with trans-abdominal transducer (Acuson scanner, using 3.5–7.5 MHz transducer; PMRI performed with phased array coil of 1.5 T Siemens MRI scanner, with T1 and T2-weighted axial and coronal images. The diagnosis of PCOS defined according to Rotterdam PCOS consensus Workshop (Hum Reprod 2004; 19: 41–7).

Results: Six adolescent girls (mean age 15.2 years, mean BMI 34.91 kg/m2, mean age at menarche 12.03 years), with menstrual irregularities, acanthosis nigricans (5/6), acne, hirsutism, and biochemical characteristics of PCOS (high plasma androgens, insulin resistance, glucose/insulin ratio <4.5, decreased SHBG) were identified. PUS was not contributive, but PMRI showed typical aspect with well delineated peripheral ovarian cysts, increased ovarian volume and stroma.

Conclusion: PUS remains gold standard diagnostic tool for PCOS, its limitations in overweight and obese girls are real and should be known. Endo-vaginal transducer cannot, however, be utilized in young virgin girls. PMRI is a useful and accurate alternative, allowing greater delineation of structural components of the ovary and better appreciation of its volume or structural alterations.

Volume 84

54th Annual ESPE (ESPE 2015)

Barcelona, Spain
01 Oct 2015 - 03 Oct 2015

European Society for Paediatric Endocrinology 

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