ESPE Abstracts

Background: Endocrine disruptors cause harmful effects to human body through various exposure routes. These chemicals mainly appear to interfere with the endocrine or hormone systems. Bisphenol A (BPA) is known as an endocrine disruptor with an estrogenic effect and it is supposed that it may have a role on development of precocious puberty (PP). Kisspeptin, a hypothalamic peptide, is a neuromodulator of GnRH and it has a big role on regulation of the onset of puberty.

Objective and hypotheses: In this study we investigated the BPA levels in girls with PP and premature telarche (PT) and its relation with kisspeptin levels.

Method: Twenty-eight girls with PP, 28 girls with PT and 22 prepubertal girls as a control group were enrolled to the study. Urinary BPA and serum kisspeptin levels were compared in groups. Bivariate correlations were performed to evaluate the relation of BPA with kisspeptin and estradiol.

Results: There was no statistical difference between groups regarding BPA levels. Serum kisspeptin levels were higher than control group (306.56 (23.69–926.15) vs 157.62 (22.54–650.41) p:0,031). There were no correlations between BPA and kisspeptin levels (r:0.185, p:0.102) and between BPA and estradiol (r:0.115, p: 0.331).

Conclusion: The relation of BPA levels with PP or PT and especially correlation with kisspeptin levels could not be demonstrated in our study. The kisspeptin levels were highest in PP group, This difference was not statistically significant between PP and PT groups whereas it was significant between PP and control groups.

Funding: This work was supported by the Bezmialem Vakif University Research Council (grant numbers 2013,0132)