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54th Annual ESPE

Barcelona, Spain
01 Oct 2015 - 03 Oct 2015

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Barcelona, Spain; 1-3 October 2015 Further information

Symposia

The effect of hormonal abnormalities on neurocognition

hrp0084s1.1 | The effect of hormonal abnormalities on neurocognition | ESPE2015

The Effect of Thyroid Hormones on the Brain

Rovet Joanne

Background: It is long been known that thyroid hormone (TH) is essential for brain development; however most evidence is based almost on rodent models. Since the advent of advanced neuroimaging techniques, it is now possible to study the manifestations of TH role in developing human brain.Objective and hypotheses: To examine findings from structural and functional MRI investigations of maternal hypothyroidism and congenital hypothyroidism (CH), which rep...

hrp0084s1.2 | The effect of hormonal abnormalities on neurocognition | ESPE2015

Diabetes Dysglycaemia, Cognition and the Developing Brain

Cameron Fergus

Glucose is the preferred metabolite of the brain with 25% of circulating blood glucose in adults destined for cerebral metabolism. It is intuitive then that type 1 diabetes mellitus (T1DM), a disorder characterised by perturbations in blood glucose (‘dysglycaemia’), should cause acute and chronic brain dysfunction. These cognitive and affective impacts appear to be greatest in the developing brain of children and adolescents with T1DM. Aspects of diabetic dysglycaemi...