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54th Annual ESPE

Barcelona, Spain
01 Oct 2015 - 03 Oct 2015

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Barcelona, Spain; 1-3 October 2015 Further information

hrp0084p3-1130 | Puberty | ESPE2015

Clinical Features and Pubertal Timing in Girls with Premature Adrenarche

Celik Sevinc , Kirmizibekmez Heves , Mutlu Rahime Gul Yesiltepe , Yildiz Feyza

Background: Premature adrenarche is defined as the development of axillary and/or pubic hair in association of the DHEA-S concentrations >108.4 nmol/l (40 μg/dl) before the age of eight in girls.Objective and hypotheses: This retrospective study aimed to investigate the clinical presentation, metabolic status, growth velocity and pubertal timing of girls with premature adrenarche.Method: Medical records of 117 patients wer...

hrp0084p3-1131 | Puberty | ESPE2015

Growth Outcomes in Childhood Craniopharyngioma: A Longitudinal Assessment of 21 Cases at a Single Centre

Michaelidou Maria , Losa Laura , Ederies Ashraf , Spoudeas Helen

Background: Craniopharyngiomas are rare suprasellar tumours with good survival but high endocrine morbidity. The commonest endocrinopathy is GHd which can precede diagnosis. Later obesity (BMI >+2SDS) may be treatment or tumour related.Objective and hypotheses: To evaluate endocrinopathy, height, weight and BMI outcomes after a conservative surgical treatment strategy with pre-treatment pituitary provocation tests for children diagnosed between 2009 ...

hrp0084p3-1132 | Puberty | ESPE2015

Effects of GnRH Agonists and Antagonists on Danazol-Induced Precocious Puberty Rat

Yang Aram , Huh Rimm , Kim Jinsup , Cho Sung Yoon , Jin Dong-Kyu

Background: GnRH agonists are a common treatment modality for patients with central precocious puberty.Objective and hypotheses: Danazol-induced precocious puberty rats were used as an animal model to compare the effects of GnRH analogues and to assess combinations of treatment with agonistic and antagonistic GnRH analogues.Method: A 5-day-old female Sprague–Dawley rats were subcutaneously injected with a single dose of 300 &#...

hrp0084p3-1133 | Puberty | ESPE2015

Clinical Characteristics of Girls with Atypical Precocious Puberty

Mawer Laura , Willemsen Ruben

Background: Precocious puberty, pubertal development in girls before 8 years, has considerable biological, psychosocial, and long-term health implications. It is classically ascribed to the premature activation of the hypothalamic-pituitary–gonadal axis, and hence an LH response >5 U/l in the LHRH test. Whilst this group of patients is well understood, there is a paucity of literature characterising patients who show pubertal development not driven by LH, atypical pre...

hrp0084p3-1134 | Puberty | ESPE2015

Paraphilic Compulsion Secondary to Dopamine Replacement Therapy and Successful Treatment with GnRH Analogues

Brewka Anna , Owen Tamsin , Lin Jean-Pierre , Ajzensztejn Michal

Background: Hypersexualized behaviour in the paediatric population is a rare phenomenon. The aetiology of paraphilia is not completely understood, but some studies suggest imbalance of the dopamine serotonin system. Paraphilia has also been described as a side-effect of treatment with monoaminooxidase inhibitors (MAOI) and dopamine agonists. Most of the currently used pharmacologic treatments of the paraphilias have serotonin and testosterone/dihydrotestosterone as their targe...

hrp0084p3-1135 | Puberty | ESPE2015

Cardiovascular Disease Risk Factors in Girls with Isolated Premature Pubarche

Nascimento Thamy Bruno , Werle Tuami Vanessa , Vargas Deisi Maria

Background: Premature pubarche is the appearance of pubic hair before 8 years in girls and 9 years in boys, being more frequent in girls. Current literature demonstrates associations between premature pubarche and metabolic and cardiovascular diseases.Objective and hypotheses: To evaluate the frequency of cardiovascular disease risk factors in girls with isolated premature pubarche (IPP).Method: Observational study using data from ...

hrp0084p3-1136 | Puberty | ESPE2015

Menstruation Pattern in Idiopathic Central Precocious Puberty Girls after Discontinuing GnRH Agonist Therapy

Chai-udom Rapeepun , Wacharasindhu Suttipong , Rungruxsirivorn Tassawan

Background: GnRH agonist (GnRHa) has been used in treatment of idiopathic central precocious puberty (ICPP) girls for more than 20 years. However, the menstruation pattern after discontinuation of treatment has been rarely reported.Objective and hypotheses: To evaluate menstrual patterns in ICPP girls after discontinuing GnRHa therapy.Method: Menstrual diary was recorded for 3 consecutive months by ICPP girls after discontinuation ...

hrp0084p3-1137 | Puberty | ESPE2015

Age of Menarche and Near Final Height after Long-Term Use of GNRH Agonist or Combined with GH in Idiopathic Central Precocious Girls

Gyon YunHee , Yun Yeong Ju , Han Heon-Seok , Kim Yong-Dae , Yu Jae-Hong

Background: The use of GnRHa in central precocious puberty is known to slow puberty progression, subsequently prevent early menarche, and attenuate the height loss by advanced skeletal maturation. But enhancing the final height was so controversial that an additional approach has been used.Objective and hypotheses: To investigate the age of menarche, and the height outcomes in central precocious girls treated with GnRHa (n=61) or combined GH (<e...

hrp0084p3-1138 | Puberty | ESPE2015

Psychosocial Changes after GnRH Agonist Treatment in Girls with Idiopathic Central Precocious Puberty

Yang Seung , Shim Young Suk , Kang Min Jae , Oh Yeon Joung , Hwang Il Tae

Background: In precocious puberty, girls experienced secondary sexual development earlier psychologically as well as physically. Self-stress due to a different body shape from the peer group, psychological concerns due to discrepancies between physical and chronological age, and long-term behavioural problems could occur.Objective and hypotheses: The aim of this study was to evaluate psychosocial changes in girls with precocious puberty between before an...

hrp0084p3-1139 | Puberty | ESPE2015

Multicentre Study of Early Screening and Prevention of Prader–Willi Syndrome

Lu Wei , Xi Li , Cheng Ruo-Qian , Li Xiao-Jing , Zhang Miao-Ying , Zheng Zhang-Qian , Ye Rong , Zhao Zhu-Hui , Shen Shui-Xian , Luo Fei-Hong

Background: The current diagnostic criteria for Prader–Willi syndrome (PWS) although widely accepted, is challenging to be implemented in Chinese population.Objective and hypotheses: The present study collected PWS cases from 12 centres across China. By analysing the clinical manifestation during early infancy, we aimed to provide data for clinical characteristics, screening strategy and effect of GH treatment in Chinese PWS patients.<p class="a...

hrp0084p3-1140 | Puberty | ESPE2015

A Novel GLUT1 Mutation in a Patient with Apparently Normal Cerebrospinal Fluid Glucose Level

Ustyol Ala , Duman Mehmet Ali , Hatipoglu Halil Ugur , Elevli Murat , Duru Hatice Nilgun Selcuk

Background: Glucose is the main energy source for the brain’s cells. Glucose transporter 1 (GLUT1), encoded by the SLC2A1 gene, is a membrane protein that plays an essential role in the transport of glucose across the blood-brain barrier. A mutation in GLUT1, so-called GLUT1 deficiency syndrome (GLUT1 DS; OMIM #606777), results in low levels of glucose in the cerebrospinal fluid despite normoglycaemia. GLUT1 deficiency causes a series of symptoms that ma...

hrp0084p3-1141 | Puberty | ESPE2015

Does Treatment with GnRH Analogues Affect BMI in Children with Precocious or Early Puberty?

Madhusudhana Madhavi , Willingham Linda , Gupta Sanjay , Matthew Verghese

Background: Treatment of precocious puberty with GnRH analogues is well established. But there are concerns about weight gain in patients on this treatment. There have been conflicting reports about the effect of GnRH analogues on weight.Objective and hypotheses: To assess the change in BMI in children treated with GnRH analogues within a UK Endocrine Service and to analyse the patient/parent experience of the treatment.Method: A r...

hrp0084p3-1142 | Puberty | ESPE2015

Qualitative Assessment of Precocious Puberty-Related UCC (User Created Contents) on YouTube

Nam Hyo-Kyoung , Bang Soo Min , Baek Joon Woo , Rhie Young-Jun , Lee Kee-Hyoung

Background: Precocious puberty is one of the fastest-growing paediatric diseases in South Korea. As the UCC (User Created Contents) has provided lots of medical information, it becomes an easy and important source of medical information.Objective and hypotheses: This study aimed to investigate and to evaluate the quality and scientific accuracy of precocious puberty-related UCC on Youtube.Method: The key words ‘precocious pube...

hrp0084p3-1143 | Puberty | ESPE2015

Premature Adrenarche is Associated to Precocious Thelarche but not to Precocious Gonadarche or Pubarche in Chilean Adolescents

Pereira Ana , Corvalan Camila , Mericq Veronica

Background: Premature adrenarche (PA) has been associated to increased metabolic risk. Areas of controversy regarding associated co-morbidities are precocious pubarche, PCOS and lower birth weight, which may depend on ethnic background.Objective and hypotheses: To describe the risk of precocious thelarche (PT, <8 years), pubarche (PP, <8 years F, <9 years M) and gonadarche (PG, <9 years) in children with premature adrenarche.<p class=...

hrp0084p3-1144 | Puberty | ESPE2015

Central Precocious Puberty in Cerebral Palsy

Bruzzi Patrizia , Messina Maria Francesca , Bartoli Alessandra , Lucaccioni Laura , Predieri Barbara , De Luca Filippo , Iughetti Lorenzo

Background: Children affected by cerebral palsy (CP) could experience central precocious puberty (CPP) 20 times more than general population. Nevertheless, the treatment is challenging.Objective and hypotheses: To compare CPP features and the effects of gonadotropin-releasing hormone agonist therapy (GnRHa) in children with CP and in controls.Method: The study involved 16 children with CPP and CP (median age (range) at diagnosis of...

hrp0084p3-1145 | Puberty | ESPE2015

Changes in BMI During GNRH Agonist Treatment in Girls with Idiopathic Central Precocious Puberty and Early Puberty

Lee Hae Sang , Jeong Hwal Rim , Kim Eun Young , Hwang Jin Soon

Background: GNRH agonist (GnRHa) has been widely used for decades to treat in patients with central precocious puberty (CPP). There are severe studies concerning changes in body composition in CPP patients following GnRHa treatment, but the results are inconsistent.Objective and hypotheses: The aim of this study was to investigate the change of BMI in children treated with GnRHa for 2 years. Also, the present study was performed to assess whether BMI aff...

hrp0084p3-1146 | Puberty | ESPE2015

An Elevated Tumour Marker and Adrenarche in a Child Using Lavender Oil: A Case Report

Lathrop Susan

Background: ‘D’ was a 7 year old Caucasian female who presented with a history of adult-type body odour starting at age 3 years. At age 6y 9m her bone age was 7y 10m. She had had a sharp increase in her weight in the past 2 years and her PCP noticed pubic hair growth. Her very anxious single mother was convinced she had a serious illness that needed immediate intervention.Case presentation: At presentation, D had Tanner 2 pubic hair and Tanner ...

hrp0084p3-1147 | Puberty | ESPE2015

Persistent Isolated Cyclical Vaginal Bleeding (Premature Menarche) not Associated with GnRH Pubertal Response or Endometrial Echo Should be Considered for Examination Under General Anaesthesia

Upadrasta Swathi , Watson Lauren , Natarajan Anuja , Ng Sze May

Background: Isolated prepubertal menarche is described in the absence of any other signs of precocious sexual development. This condition remains unclear in its aetiology and there is currently no consensus on investigations to be undertaken.Objective and hypotheses: The objective of our study is to evaluate the following factors associated with persistent isolated cyclical vaginal bleeding: clinical presentation, gonadotrophin-releasing hormone (GnRH) s...

hrp0084p3-1148 | Puberty | ESPE2015

Endocrine Dysfunction in Hypothalamic Hamartoma Depends on Presentation (Endocrine or Epileptogenic), Radiological Characteristics and Surgery

Caredda Elisabetta , Wilkinson Robert , Ederies Ash , Improda Nicola , Varadkar Sophia , Cross Helen , Tisdall Martin , Spoudeas Helen A

Background: Hypothalamic hamartomas(HH)-rare heterotopic congenital malformations (incidence 1:200 000)-present with central precocious puberty (CPP) or gelastic seizures (GS) but their natural history and best treatment strategy are unknown. Given their proximity to the hypothalamus–pituitary axis, wider endocrine dysfunction may be expected.Objective and hypotheses: To describe clinical features and any evolving endocrinopathies in HH patients, by...

hrp0084p3-1149 | Puberty | ESPE2015

Idiopathic Central Precocious Puberty – Treatment Criteria

Serra-Caetano Joana , Coutinho Rita , Almiro Maria Miguel , Guelho Daniela , Dantas Rosa , Cardoso Rita , Dinis Isabel , Mirante Alice

Background: Central precocious puberty is due to premature activation of the hypothalamo–pituitary–ovarian axis. In girls it is idiopathic in up to 95%. Children with clinical rapid progression are treated with prolonged activity GnRH agonist.Objective and hypotheses: Characterise cases of idiopathic central precocious puberty (ICPP) followed at our hospital comparing the group treated with GnRH agonist (group A) with the group not treated (gro...

hrp0084p3-1150 | Puberty | ESPE2015

Physiological Dose Reverse Rhythm Testosterone Treatment Abolishes the Development of Permanent Gynaecomastia in Adolescent Boys with 47,XXY Klinefelter Syndrome

Butler Gary

Background: Gynaecomastia (GM) is common in boys with Klinefelter syndrome (KS) during adolescence due to the higher diurnal oestradiol–testosterone ratio in early-to-mid puberty. The physiological mid-late pubertal rise in testosterone (T) causes the GM to disappear in chromosomally normal boys, but GM persists in boys with KS if this rise in T is blunted.Aims and objectives: We aimed to examine the effect of routine T supplementation in boys with ...

hrp0084p3-1151 | Puberty | ESPE2015

Urinary Bisphenol A and Its Relation with Kisspeptin in Girls with Idiopathic Central Puberty Precocious and Premature Telarche

Ozgen Ilker Tolga , Torun Emel , Bayraktar-Tanyeri Bilge , Durmaz Erdem , Cesur Yasar

Background: Endocrine disruptors cause harmful effects to human body through various exposure routes. These chemicals mainly appear to interfere with the endocrine or hormone systems. Bisphenol A (BPA) is known as an endocrine disruptor with an estrogenic effect and it is supposed that it may have a role on development of precocious puberty (PP). Kisspeptin, a hypothalamic peptide, is a neuromodulator of GnRH and it has a big role on regulation of the onset of puberty.<p c...

hrp0084p3-1152 | Puberty | ESPE2015

Prevalence of Parental Consanguinity in Children with Precocious Puberty and Kisspeptin Gene Polymorphisms

Hashemipour Mahin , Hovsepian Silva , Mazaheri Ali , Salehi Mansour

Background: Precocious puberty (PP) is one of its variations which defines as appearance of physical signs of sexual development in a child prior to the earliest accepted age of sexual maturation, 7 years in girls and 9 years in boy. The exact mechanisms and genetic background of ICPP are not well understood. It is suggested that the kisspeptin neuropeptide, encoded by the KISS1 gene, could have role in this regard.Objective and hypotheses: Considering t...

hrp0084p3-1153 | Puberty | ESPE2015

Effects of Nutrition and Vitamin D Deficiency on Central Puberty Precocious

Bayraktar Hatice Asli , Kirmizibekmez Heves , Koksal Eda

Background: Puberty is a dynamic period of physical growth. Genetic factors, increasing prevalence of adiposity, environmental factors and the widespread presence of endocrine-disrupting chemicals are suspected to contribute to the trend of earlier pubertal onset.Method: The study group consists of 32 girls diagnosed with central puberty precocious. The eating habits and physical activity status were evaluated with a detailed questionnaire. Daily calorie...

hrp0084p3-1154 | Puberty | ESPE2015

The Relationships between Serum Vitamin D Level and Precocious Puberty in Korean Girls

Kim Se Young , Woo Yeoloon

Background: The recent articles showed a kind of associations of the serum vitamin D levels and chronic diseases, for example, autoimmune diseases, vascular disorders, as well as malignancies. Also vitamin D deficiency impacts normal growth and maximal bone mineral accretion in puberty. Of pediatric population in Korea, the prevalence of cases of vitamin D deficiency and precocious puberty were continuously increasing nowadays.Objective and hypotheses: W...

hrp0084p3-1155 | Puberty | ESPE2015

Familial Precocious Puberty: Clinical Characteristics and GnRH Agonist Response

Jeong Hwalrim , Kwon Eun Byul , Lee Hae Sang , Lim Jung Sub , Hwang Jin Soon

Background: Familial precocious puberty is defined by the existence of more than one affected member either in the proband generation or in the pedigree. Recently, several gene mutation cause familial CPP is elucidated, gain of function mutations in KISS1 and KISS1R, loss of function mutations in the MKRN3, the feature of familial precocious puberty is not fully understood.Objective: To investigate the clinical characteristics of familial precocious pube...

hrp0084p3-1156 | Puberty | ESPE2015

Eating Disorders in Greek Adolescents: Frequency and Characteristics

Kyrgios Ioannis , Papageorgiou Vagia , Kotanidou Eleni , Kokka Paraskevi , Kleisarchaki Angeliki , Mouzaki Konstantina , Tsara Iro , Efstratiou Efthimia , Haidich Anna-Bettina , Galli-Tsinopoulou Assimina

Background: Eating disorders constitute serious mental disorders, characterized by a wide range of dysfunctional behaviors related to food. The term mainly includes anorexia nervosa, bulimia nervosa and binge eating disorder, and is closely related to onset during puberty. The study herein, presents the preliminary results of a school-based intervention trial regarding body weight disorders among Greek adolescents.Aims and objectives: To explore the prev...

hrp0084p3-1157 | Puberty | ESPE2015

Assessment of Endocrine Function in Egyptian Adolescent B-Thalassemia Major Patients

Dayem Soha Abd El , Kader Mona Abd El

Objective: To evaluate the endocrine function among Egyptian adolescent thalassemic patients.Patients and methods: 54 patients and 28 age-matched normal controls was included. Anthropometric measurements, clinical pubertal assessment were done for all patients. Oral glucose tolerance test (OGTT) was done to all patients and controls with measuring serum insulin level at 0.120 minutes. Insulin sensitivity and release index were calculated. 32 patients had...

hrp0084p3-1158 | Puberty | ESPE2015

Evaluation of the Effect of Two Different GnRH-Agonist Therapies on the Anthropometric Measurements in Girls with Idiopathic Central Precocious Puberty

Guven Ayla

Background: The GnRH-agonists are the drugs of choice for therapy of idiopathic-CPP. To assess two different GnRH-agonist (Leuprolide acetate: LA vs Triptorelin depot: TD) treatment effects on anthropometric measurements.Patients and methods: 74 girls with ICPP (mean age 33.8±8 years) were enrolled the study. Complaints had been begun before 8 years old. 50 girls underwent GnRH stimulation test. 58 girls with ICPP were followed up 18 months. Childre...

hrp0084p3-1159 | Puberty | ESPE2015

Testotoxicosis: Be Careful to Predict the Final Height!

Souza Leticia Guimaraes de , Bastos Paula de Magalhaes Velasco , Pinheiro Claudia Teixeira Cabido , Steinmetz Leandra , Cominato Louise , Dichtchekenian Vae , Manna Thais Della , Kuperman Hilton , Filho Hamilton de Cabral MEnezes , Damiani Durval

Background: Familial male-limited precocious puberty, known as testotoxicosis, is an autosomal dominant disease that leads to the activation of luteinizing hormone receptor. It presents with progressive virilization, advanced bone age and linear growth acceleration and may lead to loss in predicted adult height. We report the case of a patient diagnosed with testotoxicosis at two years of age.Case presentation: Two-year-old boy with penis enlargement and...

hrp0084p3-1160 | Puberty | ESPE2015

Central Precocious Puberty Presented due to Late Started Treatment for Familial Testotoxicosis

Kor Yilmaz , Durmaz Erdem , Bulus Derya , Ceylaner Serdar

Background: Peripheral precocious puberty (GnRH independed): precocious development of secondary sexual characteristics may also be caused by mechanisms that do not involve activation of pulsatile GnRH secretion. Familial male-limited precocious puberty, also known testotoxicosis is a rare dominant form of gonadotropin independent precocity caused by constitutively activating mutations of the human LH choriogonadotropin receptor (LHCGR). If do not treat with appropriate drugs ...

hrp0084p3-1161 | Puberty | ESPE2015

A Practical and Integrative Approach to Differential Diagnosis Between Precocious Puberty and Premature Telarch: Newly Proposed Clinical and Laboratory Finding-Based Diagnostic Scoring in Precocious Puberty and Premature Telarch

Karaoglan Murat , Keskin Mehmet , Ozkur Ayhan , Keskin Ozlem

Background: Accurate and differential diagnosis of preococious puberty (PP) have some important challenges. Many parameters have used to diagnose pubertal diseases so far. However LH-RH stimulation test is considered as a gold standard procedure, ıt has some difficulties in practise.Objective: We aimed to set a newly proposed clinical and laboratory finding-based diagnostic scoring in the differential diagnosis of preoccious puberty and premature te...

hrp0084p3-1162 | Puberty | ESPE2015

Delayed Puberty in Girl: Clinical and Aetiologic Study

Haddam Ali El Mahdi , Fedala Soumeya Nora , Chentli Farida , Meskine Djamila

Background: Delayed puberty in girls is evoked at the absence of breast development after the age of 13 years. It is relatively rare and must look contrary to the boy an organic cause.Objective and hypotheses: Search the frequency and aetiology of delayed puberty in girls.Method: This is a retrospective study of patients consulting for delayed puberty and collected in 5 years. The of patients was compared to the number of delayed p...

hrp0084p3-1163 | Puberty | ESPE2015

Pubertal Development Anticipation

Guidoni Elisa , Franceschini Michela , Mucaria Cristina , Scarinci Renato , Municchi Giovanna

Background: Pubertal timing is influenced by a complex interaction among genetic, nutritional, environmental and socioeconomic factors. Over the past 30 years a trend in pubertal timing anticipation has been demonstrated. Environmental factors involved in this phenomenon are mainly represented by endocrine disruptors compounds (EDCs), such as pesticides, industrial compounds and persistent organic pollutants, estrogens and phytoestrogens.Objective and hy...

hrp0084p3-1164 | Puberty | ESPE2015

The Relationship between Xenoestrogens Exposure and Early Puberty among Young Females Living in Jeddah, Saudi Arabia

Alnwsany Nouf , Al-Agha Abdulmoein

Background: Xenoestrogens are artificial oestrogen compounds, found in our environment throughout various chemical products, and claimed to affect the process of early puberty among young females.Objective and hypotheses: To investigate the relationship between exposure to xenoestrogen products and early pubertal sex development.Method: Cross-sectional study conducted in Jeddah, Saudi Arabia in July 2014 (n=568), pubertal ...

hrp0084p3-1165 | Puberty | ESPE2015

One Year Follow-Up of Asymptomatic Precocious Puberty; Clinical and Laboratory Characteristics

Jang Kyung-Mi , Cho Eun-Mi , Ko Cheol-Woo

Background: Children with bone-age advancement without any pubertal sign (asymptomatic precocious puberty, asmyptomatic PP) were reported (CW Ko,et al, at the Annual Meeting of ESPE, 2012 and 2013).Objective and hypotheses: In our follow-up study, some more children with asmyptomatic PP were enrolled additionally. We analysed their clinical and laboratory characteristics at the time of diagnosis, and they were followed-up prospectively t...

hrp0084p3-1166 | Puberty | ESPE2015

Functional MRI of a Female Teenager of Prada-Willi Syndrome Complicated with Mosaic Turner Syndrome

Wang Wei , Li Juan , Sun Ying , You Hui , Ma Chao , Song Hongmei , Zhao Weigang

Background: A patient with both Prader-Willi syndrome and mosaic Turner syndrome is extremely rare. We performed fMRI and euglycaemic-hyperinsulinaemic clamp test for her.Case presentation: A 17-yr-old girl was diagnosed as Prader-Willi syndrome by her clinical investigations including poor feeding in infancy, hyperphagia, developmental delay, mental disorders, behavior problems, thin upper lip, almond-shaped eyes, acromicria and genital hypoplasia. Mate...

hrp0084p3-1167 | Puberty | ESPE2015

In a Severe Precocious Puberty Case Who Treated with Frequent Leuprolid Acetate Injections, a Rare Adverse Effect: Sterile Abscess

Keskin Mehmet , Karaoglan Murat , Demir Korcan , Keskin Ozlem

Introduction: GnRH analogues common used in precocious puberty are highly effective agents. The drug dose and injection frequency should be designed for each case. However these agents are common well tolerated, some rare adverse effects may be occur. We present a case of frequent leuprolid acetate injections-related sterile abscess.Case: The case was 16-month-old boy. He had rapid growth, big penis, and excessive pubic hair. These symptoms have appeared...

hrp0084p3-1168 | Puberty | ESPE2015

Endocrinopathies in a 17-Year-Old Girl with Diamond–Blackfan Anemia and Transfusion-Associated Iron Overload

Ilyina Elena , Papusha Ludmila , Smetanina Natalya , Gvozdev Alexey

Background: Diamond–Blackfan anemia (DBA) is an inherited bone marrow failure syndrome, which presents with anemia in early infancy. Survival depends on blood transfusions, which in consequence lead to iron overload (IOL). The most common complications of IOL are hepatic cirrhosis, endocrinopathies and cardiomyopathy.Results: We present the case of 17 years old girl with DBA and IOL-associated endocrinopathies. Her treatment consists of multiple blo...