ESPE Abstracts (2015) 84 P-3-1088

Perinatal

Leptin and Neuropeptide Y Levels in Newborns

Avni Kayaa, Zerrin Orbaka, Ismail Polata, Harun Polatb & Musa Gümüsdereb

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aDepartment of Pediatric Endocrinology, Faculty of Medicine, Ataturk University, Erzurum, Turkey; bDepartment of Biochemistry, Faculty of Medicine, Ataturk University, Erzurum, Turkey


Background: Several studies have investigated leptin and NPY levels in children, but the information for newborns in the literature is limited.

Objective and hypotheses: The aim of this study was to determine leptin and neuropeptide Y (NPY) levels in between 14 and 28-days newborns.

Method: This prospective study was performed in the Erzurum Atatürk University Medical Faculty Research Hospital Neonatal Clinic, Turkey, between July and December 2014. Sixty-two 14–28-day-old babies, 26 female and 36 male, were included in the study. Patient age, height and body weight were recorded. Feeding status was recorded. Babies were divided into two groups, those receiving breastfeeding only and those receiving breastfeeding and formula. Plasma leptin levels were measured by the enzyme amplified sensitivity immüno assay and plasma NPY levels were measured by the enzyme immüno assay method. Leptin and NPY levels were expressed as nanograms/milliliter.

Results: In the 14–28 day-old-girls mean leptin level of was 4.25±3.08 ng/ml and mean NPY level 24.79±9.87 ng/ml. In the 14–28 day-old-boys mean leptin level of was 3.49±2.52 ng/ml and mean NPY level 25.80±9.58 ng/ml. No significant difference was also determined between leptin (P=0.228) or NPY (P=0.144) in terms of feeding status. No significant difference was observed between the sexes in terms of leptin or NPY levels (leptin P=0.775 and NPY P=0.687).

Conclusion: There were no difference respect to feeding status and sex of leptin and NPY levels in the neonatal period.

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