ESPE Abstracts (2015) 84 P-3-1162

Puberty

Delayed Puberty in Girl: Clinical and Aetiologic Study

Ali El Mahdi Haddama, Soumeya Nora Fedalab, Farida Chentlib & Djamila Meskinea

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aDepartment of Endocrinology Bologhine Hospital, Algiers, Algeria; bDepartment of Endocrinology Bab el Oued Hospital, Algiers, Algeria


Background: Delayed puberty in girls is evoked at the absence of breast development after the age of 13 years. It is relatively rare and must look contrary to the boy an organic cause.

Objective and hypotheses: Search the frequency and aetiology of delayed puberty in girls.

Method: This is a retrospective study of patients consulting for delayed puberty and collected in 5 years. The of patients was compared to the number of delayed puberty observed in boys. All patients underwent a complete clinical examination, a gonadal balance (FSH, LH, E2) and a radiological assessment (wrist and the left hand X-ray, pelvic ultrasound). A complementary paraclinical exploration was carried out depending on the etiological context (karyotype, ovarian or adrenal androgens exploration, hypophysiogramm, MRI HH.). All patients were followed and reassessed every six months.

Results: 60 cases have been reported vs 110 in boys. The average age in the consultation was 15.8 years (14–20). Etiological exploration revealed an organic cause in 2/3 of cases: turner syndrome35%, Idiopathic hypogonadotropic hypogonadism 15%, Kalmann syndrome 10%, autoimmune oophoritis 3% hypogonadotropic hypogonadism post radiotherapy 3%, PCOS2%. In 32% of cases, it was a simple delayed puberty.

Conclusion: In accordance with the literature, delayed puberty in girls is twice less than boys. It is usually organic, and must be explored early. In all cases, early and prolonged management is essential to ensure optimal growth and pubertal development and normal reproductive function.

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