ESPE Abstracts (2015) 84 P-3-754

Diabetes

Thyroid Function and Prevalence of Celiac Disease in Children with T1D in Lithuanian Pediatric Population

Ingrida Stankutea, Rimante Dobrovolskienea, Edita Jasinskienea, Giedre Mockevicienea, Brone Urbonaitea, Dalia Marciulionytea, Nijole Jurgevicienea & Valerie Schwitzgebelb

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aInstitute of Endocrinology, Lithuanian University of Health Sciences, Medical Academy, Kaunas, Lithuania; bChildren’s University Hospital, Pediatric Endocrine and Diabetes Unit, Geneva, Switzerland


Background: Patients with type 1 diabetes (T1D) are at higher risk for developing coexisting autoimmune diseases.

Objective and hypotheses: To evaluate thyroid and celiac disease prevalence in children with T1D in Lithuanian paediatric population.

Method: 777 patients (49.7% males) <18yrs with T1D, covering all T1D pediatric Lithuanian population, were examined. Serum free thyroxine (FT4), thyrotropin (TSH), antithyroid peroxidase (ATPO) and tissue transglutaminase antibodies (tTG-A) were measured.

Results: Mean age of patients was 12.1±4.4 years (0–4 years 7.9%, 5–9 years 23.4%, 10–14 years 36.9%, 15–18 years 31.8%). Mean duration of T1D was 3.9±3.9 years, in 68.1% duration of disease was <5 years. The average level of HbA1c was 8.75±2.22%. 33.7% of children had HbA1c <7.5%. Thyroid dysfunction was detected in 17.6% of cases. Hypothyroidism was evident in 0.4%, subclinical hypothyroidism – in 16.6%, hyperthyroidism – in 0.6% of cases. Thyroid dysfunction was significantly more prevalent in females (P=0.053). ATPO were positive in 12% of cases. There was a significant association between positive ATPO and thyroid dysfunction (r=−0.165, P<0.001). No significant associations between thyroid dysfunction and metabolic control were found. Positive tTG-A were found in 4%. No significant correlations between positive tTG-A and HbA1c or duration of T1D were found (P=0.947 and P=0.062, respectively).

Conclusion: Thyroid dysfunction was more common in females and in patients with positive ATPO antibodies. The prevalence of positive tTG-A in Lithuanian children with T1D is similar to data from most other countries.

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