ESPE2016 Late Breaking (1) (13 abstracts)
Impact of Weight Loss after Bariatric Surgery on Gonadic Function in Severely Obese Female Adolescents
Madeleine Gottrand a , Estelle Aubry b , Aurelien Aumar c , Robert Caiazzo d , Maryse Cartigny a , Marie Pigeyre e , Francois Pattou d & Iva Gueorguieva a
aPaediatric Endocrinology, Lille University Hospital, Lille, France; bPaediatric Surgery, Lille University Hospital, Lille, France; cUpper Limb Orthopaedic Surgery, Lille University Hospital, Lille, France; dDepartment of General and Endocrine Surgery, Lille University Hospital, Lille, France; eDepartment of Nutrition, Lille University Hospital, Lille, France
Background and objectives: To study short-term effects of consequent weight loss on ovarian function and its correlation with morphometric and metabolic changes at 1 and 2 years after a laparoscopic adjustable gastric banding (LAGB) placement in severely obese adolescents.
Subjects and methods: Our retrospective and observational study was conducted between July 2015 and January 2016 in a single center. Menstruations, anthropology and biological data were collected prospectively before LAGB (M0, n=17), one (M12, n=15) and two (M24, n=9) years after surgery. Data of seventeen female adolescents, operated between April 2011 and November 2015, were included in the study (M0). Description of morphometric changes was made with calculation of BMI, excess body weight (EBW) and excess weight loss (%EWL). Metabolic changes were described using homeostatic model assessment (HOMA) for insulin resistance; gonadic function parameters were age at menarche, cycle length and serum androgen levels (testosterone) in adolescents free from oral contraception.
Results: Mean BMI of our population before surgery was 42.4±6.7 kg/m2. At M12, mean EWL was 19.7±14.1%. Age at menarche was significantly younger in obese adolescents compared to mean age of menarche of their mothers (11.6±1.5 vs 12.3±1.8 years old, P=0.05). Mean of cycle length in our population moved from 60.7±34.9 days before surgery to 26.0±3.4 days after surgery (P=0.014). Cycle length without hormonal contraception correlated positively with BMI before surgery (r=0.687 P=0.043). Neither insulin sensitivity (HOMA), nor testosterone level changed significantly at both 1 and 2 years after bariatric surgery.
Conclusion: Consequent weight loss seems to have effects on improvement of ovarian function by normalizing menstruation cycle length in severely obese female adolescents, despite modest metabolic and hormonal changes.
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