ESPE2016 Poster Presentations Fat Metabolism and Obesity P1 (48 abstracts)
aDepartment of Endocrinology, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación Sanitaria La Princesa, Department of Pediatrics, Universidad Autónoma de Madrid, Madrid, Spain; bCIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain
Background: Dietary carbohydrate restriction in the treatment of obese adolescents could cause a substantial shift in the substrates used as an energy source, inducing changes on body composition and metabolism, but experience in this age range is limited.
Objective: We assessed the influence of 6 months of dietary carbohydrate restriction on body composition and lipid and carbohydrate metabolism in obese adolescents.
Method: Thirty-six (15.8±1.5 years; 22 girls/14 boys) obese (+4.72±2.80 BMI-SDS) Caucasian adolescents were recruited and analyzed monthly. Two nutritional interventions with similar caloric content (1500 kcal/day) were compared: limited carbohydrates (CH-L, n=19, 10% carbohydrates for 4 months and 30% later) vs. unrestricted carbohydrate diet (CH-N, n=17, 52% carbohydrates). Patients were studied at recruitment (R) and after 3 (3M) and 6 months (6M). BMI, body composition (BIA, Tanita® BC-420MA), glycemia, insulinemia, HOMA, lipid profile, uric acid and serum 25[OH]vitamin-D levels were recorded.
Results: Both groups reduced their BMI-SDS at 6M (P<0.001), with this being greater in the CH-L group (−1.70±0.98 vs −0.80±1.09 in the CH-N; P<0.05) due to a larger reduction in the first 3 months (−1.41±0.71 vs. −0.62±0.78 in the CH-N; P<0.001) as the BMI-SDS evolution between 3 and 6 months was similar. This loss in BMI was due to a decrease in fat mass. A transient rise in uricemia was observed in the CH-L group at 3M (P<0.01), which normalized at 6M. HOMA improved exclusively in the CH-L group at 6M (−1.75±1.48 vs. +0.15±1.25 in CH-N; P<0.001). No significant differences within or between groups were observed in the evolution of the lipid profile, but both groups showed an increase in vitamin-D levels at 6M after weight loss (P<0.001).
Conclusion: Diet carbohydrate restriction results in a more intense weight reduction and insulin resistance improvement in obese adolescentes after 6 months of treatment.