ESPE Abstracts

Background: Vitamin D deficiency has been associated with chronic diseases, such as diabetes mellitus, obesity and autoimmune disease. However, There are only a few studies about the correlation between Vitamin D levels and precocious puberty in girls.

Objective and hypotheses: In the previous study, vitamin D levels may be associated with precocious puberty. We also aimed to re-evaluate the relationship between serum 25-hydroxyvitamin D (25(OH)D) and precocious puberty in girls.

Method: A total of 155 girls with central precocious puberty (CPP) and 45 control girls were enrolled. Anthropometric measurement and serum level of 25(OH)D were estimated for all subjects.

Results: Mean 25(OH)D level of CPP group was 17.3±5.6 ng/ml, which was lower than the control group (19.0±5.3 ng/ml). There was significant difference in the mean serum 25OHD concentration between the precocious puberty group and the control group (P=0.042). After 25(OH)D levels be classified by month(season), Significant difference in the mean serum 25(OH)D concentration between the two groups was only winter (December–February). 113 of the 155 girls with CPP (72.9%) had 25(OH)D deficiency (defined as serum 25(OH)D <20 ng/ml) and 38 (24.5%) had 25(OH)D insufficiency. Of the 45 girls in the control group, 25(OH)D deficiency was seen in 24 subjects (53.3%), 20 subjects (44.4%) had 25(OH)D insufficiency, and 1 subjects (2.2%) had sufficient serum 25(OH)D (defined as serum 25(OH)D >30 ng/ml). The prevalence of 25(OH)D was significantly higher odds ratio (OR, 2.35; 95% CI, 1.18–4.66, P=0.017) among CPP group than controls.

Conclusion: Our results showed that vitamin D level was significant association with precocious puberty. We also recommend further studies are required to identify the correlation vitamin D levels and precocious puberty.