ESPE2016 Poster Presentations Syndromes: Mechanisms and Management P2 (50 abstracts)
Quality of Life in Growth Hormone Treated Children and Adolescents with Growth Hormone Deficiency and Smallness for Gestational Age
Jean De Schepper a, , Saskia Van der Straaten b , Nele Reynaert c , Annick France d , Inge Gies a , Anne-Simon Parent e , Véronique Beauloye f , Guy Massa m , Dominique Beckers g , Claudine Heinrichs h , Karl Logghe i , Sylvia Depoorter j , Murielle Thomas k , Franciska Verlinde k & Johan Vanderfaeillie l
aUZ Brussel, Brussel, Belgium; bUZ Gent, Gent, Belgium; cUZ Leuven, Leuven, Belgium; dUZ Antwerpen, Antwerpen, Belgium; eCHU Liège, Liège, Belgium; fCliniques Universitaires Saint Luc, Bruxelles, Belgium; gCliniques Universtaires Mont Godinne, Mont Godinne, Belgium; hHUDERF, Bruxelles, Belgium; iAZ Delta, Roeselare, Belgium; jAZ Sint Jan, Brugge, Belgium; kBESPEED, Brussels, Belgium; lVUB, Brussel, Belgium; mJessa ziekenhuis, Hasselt, Belgium
Background: The potential benefit of growth hormone (GH) therapy on health-related QOL (HQoL) of children with short stature related to GH deficiency (GHD) or smallness for gestational age (SGA) has not been well documented.
Objective and hypotheses: Our objective was to assess potential disease and treatment related predictors for a poor HQoL in GH treated children. Children with male gender, SGA disorder, greater height deficit at start of GH and poor height gain were expected to be at risk.
Methodology: The QoLISSY questionnaire - a cross-culturally developed height specific instrument - was sent to 157 children with idiopathic GHD and 219 non-syndromic SGA children, between 8 and 18 years old, being treated for at least one year with GH for short stature (height SDS < −2.5) at a Belgian GH treatment center. The questionnaires were filled out by the child.
Results: Median total QoLISSY scores (tQS) of 22 (14 male) GHD and 55 (32 male) SGA children with complete data (20% response rate) were similar (76%), but significantly (P< 0.001) higher than reported in untreated short children (65%). Whereas no gender difference in tQS was present in GHD patients, SGA females had a lower median score (71.4 vs 80.9%). Despite a similar median age and height SDS at start and a similar median height gain at evaluation, height SDS at evaluation, GH exposure time as well as total height gain SDS correlated positively with tQS only in the GHD group. Using linear regression, gender and height gain were the best predictors of the tQS in the whole group.
Conclusion: In a written survey with a low response rate, GH treated SGA girls were found to have the lowest HQoL. Females and children with the lowest height gain GH appear most at risk for presenting the lowest HQoL under GH therapy.
Article tools
My recent searches
My recently viewed abstracts
Authors
ESPE Abstracts
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more