ESPE Abstracts

Background: Endoplasmic reticulum (ER) participates in so many cellular tasks that trouble can ensue when it stops working properly, including β cell death in type 1 and type 2 diabetes mellitus. Despite the underlying importance of ER dysfunction in β cell death during the progression of diabetes, there is no effective treatment targeting the ER due to the complex etiologies of type 1 and type 2 diabetes.Objective and hypotheses: Our strategy ...

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Over the past decade, work from our research group has demonstrated that over-expression or activation of the chaperone protein heat shock protein 72 (HSP72; the inducible form of the 70kDa family of heat shock proteins) in skeletal muscle reduces obesity-induced insulin resistance (for review see). These findings led to the development of the small molecule activator of HSP72, namely BGP-15 which, in pre-clinical studies, has proven to be effective in the treatment of several...