ESPE Abstracts (2016) 86 P-P1-617

The Blood Antioxidant System in Adult Growth Hormone Deficient Patients after Concluded Childhood Growth Hormone Therapy

Maria Vorontsovaa, Maria Pankratovaa, Alexander Yusipovichb, Baizhumanov Adilb, Tatyana Shiryaevaa, Elena Nagaevaa, Maximov Georgiyb & Valentina Peterkovaa

aEndocrinology Research Centre, Moscow, Russia; bMoscow State University, Moscow, Russia

Background: The antioxidant system that protects tissues from damaging oxidation processes is a universal indicator for metabolic balance. It is known that GH deficiency (GHD) is associated with a high risk of developing metabolic disorders.

Objective and hypotheses: The aim of this study was to examine the effects of inadequate GH secretion on the markers of the blood antioxidant system in adult GHD patients.

Method: The study included ten adult patients aged 18–26 years, median age 23 years, with a confirmed diagnosis of GHD since childhood. All patients received hormone therapy in childhood to achieve target height and/or closing of growth plate zones. All of the patients had not received metabolic therapy with GH after the closure of growth plate zones. 15 healthy adult volunteers were included in the control group, aged 22–35 years, median age 26 years. The blood antioxidant system was examined using superoxide dismutase (SOD) and catalase activities; ceruloplasmin (CP) concentrations; total antioxidant capacity (TAC) of plasma; non-protein thiol, and thiobarbituric acid reactive substances (TBARS) levels.

Results: Elevated TBARS and CP levels (median 5.02 vs 3.15 nMol/ml, 558 vs 387 μkg/ml, correspondingly) in GHD patients vs. healthy subjects was observed. Raised SOD activity in GHD patients (13.4 vs 21.4 a.u./g Hb) was also shown. The present work has demonstrated that parameters of the blood antioxidant system are impaired in adult GHD patients with interrupted GH treatment after having reached target height, which is indicated by oxidative stress development.