ESPE Abstracts (2016) 86 P-P2-165

Bone Health and Metabolic Syndrome in Childhood Cancer Survivors

Ju Young Yoona, Kyung-Sue Shina, Hyeon Jin Parkb, Byung Kiu Parkb, Chan-Hoo Parka, Mi Mi Kwonb, Hye Young Shimb, Sun Hwa Baekb, Hee Young Jub & Young Mi Kimb

aGyeongsang National University Changwon Hospital, Changwon Si, Republic of Korea; bNational Cancer Center, Goyang Si, Republic of Korea

Background: Metabolic syndrome and impaired bone health are common complications in childhood cancer survivors, and both are possibly related with decreased physical activities.

Objective and hypotheses: We aimed to evaluate the prevalence rates of metabolic syndrome and osteopenia in adolescent/young adult childhood cancer survivors. We also aimed to investigate the relationship between physical activity and these complications.

Method: Subjects were 88 childhood cancer survivors aged 15–25.7 years. Controls were 159 healthy participants of 2011 Korean National Health and Nutrition Examination Survey (KNHANES). Demographic and medical characteristics were obtained from the patients’ medical records. Metabolic syndrome was defined by NCEP criteria and was evaluated by physical examination and laboratory test. Physical activities were evaluated using questions from KNHANES.

Results: Eighty-eight survivors participated in the study (45 males and 43 females). Of the 52 adult participants, 42 replied to the questionnaire about physical activity. Childhood cancer survivors had higher walking performance rate than control group, and there was no significant difference in performance rate of other kinds of activities. Thirty-four (38.6%) survivors had one or more components of metabolic syndrome, and there were no differences in the prevalence rates of components of metabolic syndrome between patients and control group. Survivors had significantly lower BMDLS than normal reference population, with BMDLS z score of −0.50 (P=0.001). Prevalence rates of metabolic syndrome and osteopenia were not different according to walking performance.

Conclusion: The prevalence rates of osteopenia in young childhood cancer survivors was higher than healthy reference group, which requires earlier intervention.

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