Background: Type 2 diabetes (T2DM) increases in parallel with obesity in childhood. T2DM can be associated with cardiovascular risk (CVR) even childhood.
Objective: To investigate the presence of CVR criterions in children with T2DM and to detect CVR as the earliest age as possible.
Method: This study enrolled 84 (58 Girls) children with T2DM. OGTT was performed in 47 children. Biochemical and hormonal analyses were performed in fasting state. The presence of hepatosteatosis, polycystic ovaries and microvascular complications were investigated. At admission, atherogenic index of plasma (AIP) and atherosclerosis-index (AI) were calculated.
Results: Mean age was 13.4±2 years. Clinical features are given in Table 1. 55.1% of girls were obese and 80.7% of boys were obese. 35 patients had been followed for 24 months. The youngest patient with high AIP (>0.21) was 8.9 year-old girl and the youngest patient with high AI (>3.1) was 10.6 year-old boy. AIP was high in 90% of patients and high AI was found in 38% of them. 81.5% of them had hepatosteatosis. Autoantibodies were detected in 15 of 60 patients. 65.4% of patients had ≥3 cardiovascular risk criterions. Significant differences were found in BMI between at admission and at 3 rd, at 6 th and at 12 th months (P=0.001, P=0.024, P=0.049, respectively). There was a difference in HbA1c between at admission and at 12th months (P=0.021). BMI-at admission was correlated with systolic-blood-pressure (SBP) (0.488), diastolic-BP (r:0.450), HOMA-IR (r:0.307), Quicki (r:−0.307), FGIR (r:−0.336), AST (r:0.268) and ALT (r:0.348). AIP was positively correlated with BMI-SD at-admission (r:0.231), SBP (r:0.259), ALT (r:0.380), AST(r:0.298) and microalbuminuria (r:0.315). BMI-at admission is the determining factor on AIP (P=0.005).
|Total n:84||Girls n:58||Boys n:26|
|BMI SDS||2.3 (0.6)||2.15 (0.75)||2.4±0.4|
|HOMA-IR||5.62 (15.5)||7.45 (6.9)||6.29 (8.4)|
|FGIR||5.3 (7.41)||7.2 (14.2)||16.4 (19.5)|
|AIP, log (Triglyceride/HDL)||0.58±0.33||0.59±0.25||0.57±0.46|
Conclusion: Cardiovascular morbidity is high in T2DM. Children with T2DM have increased CVR even if younger than age of 10. BMI is the most important determining factor of CVR. AIP and AI might be useful for early diagnosis in clinical practice.
10 - 12 Sep 2016
European Society for Paediatric Endocrinology