Background: Adipose tissue acts as an endocrine organ, secreting biologically active molecules in response to external stimuli or lipid overloading. These adipose tissue-derived signaling molecules include adipokines such as leptin, adiponectin and resistin (4). On the other hand, ghrelin is the hunger hormone and an endogenous growth hormone secretagogue.
Objective and hypotheses: This study aimed to investigate the relation between weight gain and serum insulin, leptin, ghrelin, adiponectin and resistin levels in small for gestational age newborns during neonatal period.
Method: Newborns whose weight was lessthan the 10th percentale for gestational age were classified as small for gestational age newborns. Asymetrical SGA newborns were included in this study. All newborns were term.
Results: Biochemical parameters were similar for two groups (P>0.05) except for serum resistin levels at the birth. At the birth serum resistin levels were significantly lower in SGA group (P<0.01). At the end of the first month there was no difference between biochemical parameters for two groups (P>0.05). Δweight gain were negatively correlated with serum ghrelin (p<0.01) and resistin (P<0.05) levels of birth in SGA group. In control group, there was positively correlation between Δweight gain and serum insulin levels of birth (P<0.01).
Conclusion: Our results indicates that serum ghrelin and resistin levels negatively affect early posnatal growth in SGA newborns. On the other hand serum insulin levels were important in healthy newborns during early postnatal weight gain.
10 - 12 Sep 2016
European Society for Paediatric Endocrinology