ESPE Abstracts (2016) 86 P-P2-843

Syndromes: Mechanisms and Management P2

The Specific Pubertal Height Gain is Higher in Boys as Well as in Children with Lower BMISDS

Anton Holmgrena,b, Aimon Niklassona, Andreas Nieropc, Lars Gelandera, A. Stefan Aronsonb, Agneta Sjöbergd, Lauren Lissnere & Kerstin Albertsson-Wiklandf


aGPGRC, Department of Pediatrics, Intuition of Clinical Sciences, Sahlgrenska Academy, Gothenburg, Sweden; bDepartment of Pediatrics, Halmstad County Hospital, Halmstad, Sweden; cMuvara bv, Leiderdorp, The Netherlands; dDepartment of Food & Nutrition, & Sport Science, University of Gothenburg, Gothenburg, Sweden; eDepartment of Public Health & Community Medicine, Intuition of Medicine, The Sahlgrenska Academy, Gothenburg, Sweden; fDepartment of Physiology, Division of Endocrinology, Intuition of Neuroscience & Physiology, The Sahlgrenska Academy, Gothenburg, Sweden

Background: Growth in height during puberty can be described by the QEPS-model as a combination of continuous basal growth, QES, and a specific pubertal growth function, P.

Objective and hypotheses: To study the relationship between childhood BMISDS and the prepubertal gain and pubertal gain related to growth functions from the QEPS-model.

Method: The longitudinally followed GrowUpGothenburg 1990 birth cohort, was analyzed, by the QEPS-model. Individual maximal BMISDS values, from 3.5–8.0 years of age (n=1901) were calculated for linear and subgroup analyses, underweight (blue cross), normal (blue open circles), overweight (red open circles), obese (red circles).

Results: For girls (Figure left), total pubertal gain (Tpubgain) depended more on QESgain during puberty. For boys, total pubertal gain depended more on specific Pgain (Figure right). With higher BMISDS this balance was shifted towards less Pgain for both girls and boys. Before puberty, children with higher BMISDS were taller, expressed as higher QESgain, with a linear correlation over the whole BMI–range (P<0.001for both girls/ boys).

Conclusion: During puberty, girls grew more due to the QES than the P functions, with opposite findings in boys. For both boys and girls, there were less Pgain and more QES- gain with higher childhood BMISDS. Before puberty, children with higher BMISDS were taller.

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